Journal
NUTRIENTS
Volume 13, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/nu13092940
Keywords
phytochemicals; microbiota; Saccharomyces cerevisiae; Caenorhabditis elegans; Drosophila; zebrafish; rodents; human; neurodegeneration
Categories
Funding
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [804229]
- iNOVA4Health Research Unit [LISBOA-01-0145-FEDER-007344]
- Fundacao para a Ciencia e Tecnologia (FCT)/Ministerio da Ciencia e do Ensino Superior
- FEDER
- FCT [2020.04630, CEEC/04567/CBIOS/2020, UIDP/BD4/04567/2020]
- European Research Council (ERC) [804229] Funding Source: European Research Council (ERC)
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The rise of neurodegenerative diseases in an aging population poses significant health, social, and economic consequences. Diets rich in (poly)phenols have been shown to have health benefits in preventing cognitive decline and neurodegenerative diseases. The role of gut microbiota in metabolizing (poly)phenols and the potential brain effects of low molecular weight (poly)phenol metabolites still require further research.
The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration.
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