Biomaterials for Periodontal and Peri-Implant Regeneration

Periodontal and peri-implant regeneration is the technique that aims to restore the damaged tissue around teeth and implants. They are surrounded by a different apparatus, and according to it, the regenerative procedure can differ for both sites. During the last century, several biomaterials and biological mediators were proposed to achieve a complete restoration of the damaged tissues with less invasiveness and a tailored approach. Based on relevant systematic reviews and articles searched on PubMed, Scopus, and Cochrane databases, data regarding different biomaterials were extracted and summarized. Bone grafts of different origin, membranes for guided tissue regeneration, growth factors, and stem cells are currently the foundation of the routinary clinical practice. Moreover, a tailored approach, according to the patient and specific to the involved tooth or implant, is mandatory to achieve a better result and a reduction in patient morbidity and discomfort. The aim of this review is to summarize clinical findings and future developments regarding grafts, membranes, molecules, and emerging therapies. In conclusion, tissue engineering is constantly evolving; moreover, a tailor-made approach for each patient is essential to obtain a reliable result and the combination of several biomaterials is the elective choice in several conditions.

Automated summary

Periodontal and peri-implant regeneration aims to restore damaged tissues around teeth and implants with a tailored approach based on the specific characteristics of each site. Current clinical practice relies on bone grafts, membranes for guided tissue regeneration, growth factors, and stem cells, combined with a patient-centered approach to achieve optimal results and reduce patient morbidity. Tissue engineering is constantly advancing, with a combination of biomaterials as the preferred choice in many cases for achieving reliable outcomes.