Journal
GENE
Volume 591, Issue 2, Pages 313-319Publisher
ELSEVIER
DOI: 10.1016/j.gene.2016.06.035
Keywords
MicroRNA; miR-197; Biomarker; Cancer
Categories
Funding
- National Natural Science Foundation of China [81272470]
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microRNAs (miRNAs) are small noncoding RNAs that could regulate post-transcription level through binding to 3'untranslated region (3'UTR) of target messenger RNAs (mRNAs), which were reported to be related with the incidence and development of diverse neoplasms. Among them, miR-197 was confirmed to play a vital role of oncogene or anti-oncogene in different cancers via targeting key tumorigenic or tumor-suppressive genes. Additionally, miR-197 had extensively been studied in carcinogenesis progression of cancers through various mechanisms, including apoptosis, proliferation, angiogenesis, metastasis, drug resistance and tumor suppressor, and also played a role in prognosis of cancers. In this review, we summarized the roles of miR-197 in cancers and considered it as a potentially novel biomarker for different cancers, offering an alternatively secure and effective tool in molecular targeting cancer treatment. (C) 2016 Elsevier B.V. All rights reserved.
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