4.6 Article

Investigation of juglone effects on metastasis and angiogenesis in pancreatic cancer cells

Journal

GENE
Volume 588, Issue 1, Pages 74-78

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2016.05.001

Keywords

Juglone; Metastasis; Pancreatic cancer cell lines

Funding

  1. Instructor Training Program

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Juglone, a natural component, is shown to have cytotoxic and apoptotic effects in several cancer cell lines. However, little is known about its effects on invasion and metastasis. In this study, we aimed to determine the antimetastatic effect of juglone in the BxPC-3 and PANC-1 pancreatic cancer cell lines. Cytotoxic effect of juglone was evaluated by using MTT (3-(4,5-Dimethylthiazo1-2-yl)-2,5-Diphenyltetrazolium Bromide) test. The cells were treated with juglone at

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