Journal
MATERIALS
Volume 14, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ma14112723
Keywords
benzenesulfonyl hydrazones; bioactivity; antibacterial activity; MIC; MBC; ligands
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This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. The study confirmed the potential application of obtained derivatives as antimicrobial agents, with derivative 24 showing the highest activity among the tested compounds.
This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. Twenty-five hydrazones (2-26) were synthesized on the basis of condensation reaction. The in vitro bioactivity study confirmed the potential application of obtained derivatives as antimicrobial agents. Among the tested compounds, the highest activity was discovered for derivative 24, which possessed minimal inhibitory concentration (MIC) ranging from 7.81 to 15.62 mu g/mL against Gram-positive reference bacterial strains. Synthesized benzenesulfonyl hydrazones can be applied as potential ligands for the synthesis of bioactive metal complexes.
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