Journal
GENE
Volume 594, Issue 1, Pages 10-15Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2016.08.039
Keywords
PINCH; IPP complex; ILK; Nck2; Adhesion; Focal adhesion; Protein-protein interaction; Tumor
Categories
Funding
- National Institutes of Health [AR068950, AR064874]
- National Natural Science Foundation of China [81630066, 81472049, 81500160]
- Shenzhen Municipal Science and Technology Innovation Council Grant [JCYJ20150331101823686]
Ask authors/readers for more resources
Particularly interesting new cysteine-histidine-rich protein (PINCH) is a LIM-domain-only adaptor that plays important roles in cytoskeletal organization and extracellular matrix adhesion, migration, proliferation and survival. Mammalian cells have two functional PINCH proteins, PINCH1 and PINCH2. PINCH not only binds to Nck2 and engages in the signaling of growth factor receptors, but also forms a ternary complex with ILK and parvin (IPP complex). Normally, the IPP complex locates to focal adhesions participating in the signaling of integrins and mediating the interaction of cytoskeleton and extracellular matrix (ECM). Accumulative evidence indicates that abnormalities in PINCH signaling are involved in the pathogenesis of important diseases, such as cancers, renal diseases, cardiomyopathy, and HIV. Therefore, clarifying the functions of PINCH and its interactions with key factors is important for better understanding of signaling events both in health and disease. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available