Journal
CANCER DISCOVERY
Volume 11, Issue 10, Pages 2378-2395Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-21-0324
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Funding
- Cancer Research UK CRUK [C10674/A27140]
- Bloomberg Philanthropies
- NCI [R01CA196845, R00CA230192]
- Johns Hopkins School of Medicine
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This review focuses on recent investigations to identify potential microbial species associated with cancer initiation and progression at specific body sites. Emerging experimental and translational data support the microbiome's contribution to cancer biology and disease progression, suggesting that disrupting microbiome features and pathways could lead to new approaches for improving cancer outcomes in patients.
knowledge of the human microbiome, which is likely a critical factor in the initiation, progression, and prognosis of multiple forms of cancer, is rapidly expanding. In this review, we focus on recent investigations to discern putative, causative microbial species and the microbiome composition and structure currently associated with procarcinogenesis and tumorigenesis at select body sites. We specifically highlight forms of cancer, gastrointestinal and nongastrointestinal, that have significant bacterial associations and well-defined experimental evidence with the aim of generating directions for future experimental and translational investigations to develop a clearer understanding of the multifaceted mechanisms by which microbiota affect cancer formation. Significance: Emerging and, for some cancers, strong experimental and translational data support the contribution of the microbiome to cancer biology and disease progression. Disrupting microbiome features and pathways contributing to cancer may provide new approaches to improving cancer outcomes in patients.
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