Journal
BIOMEDICAL OPTICS EXPRESS
Volume 12, Issue 9, Pages 5770-5781Publisher
Optica Publishing Group
DOI: 10.1364/BOE.428430
Keywords
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Funding
- National Eye Institute [R01-EY024312]
- National Institutes of Health
- National Medical Research Council [CG/C010A/2017, OFIRG/0048/2017, OFLCG/004c/2018, TA/MOH-000249-00/2018]
- Singapore Eye Research Institute & Nanyang Technological University
- Agency for Science, Technology and Research [A20H4b0141]
- National Research Foundation Singapore
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This study proposed a method to estimate ocular shape using SS-OCT technology with distortion correction and localized Gaussian curvature to quantify ocular curvature. The research successfully measured eye shape and demonstrated its applicability in myopic individuals.
Ocular deformation may be associated with biomechanical alterations in the structures of the eye, especially the cornea and sclera in conditions such as keratoconus, congenital glaucoma, and pathological myopia. Here, we propose a method to estimate ocular shape using an ultra wide field MHz swept-source optical coherence tomography (SS-OCT) with a Fourier Domain Mode-Locked (FDML) laser and distortion correction of the images. The ocular biometrics for distortion correction was collected by an IOLMaster 700, and localized Gaussian curvature was proposed to quantify the ocular curvature covering a field-of-view up to 65 degrees x62 degrees. We achieved repeatable curvature shape measurements (intraclass coefficient = 0.88 +/- 0.06) and demonstrated its applicability in a pilot study with individuals (N = 11) with various degrees of myopia. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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