Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 14, Issue 8, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2021.103299
Keywords
Fe3O4/lignin/Cu; Reduction; Nitro compounds; A549; Human lung cancer
Categories
Funding
- deanship of Scientific Research at King Khalid University, Abha, KSA [R.G.P.2/122/42]
- Taif University, Taif, Saudi Arabia [TURSP2020/68]
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This work presents an eco-friendly approach for immobilizing Cu nanoparticles on lignin modified Fe3O4 nanoparticles, resulting in a highly efficient nanocatalyst for nitroarene reduction. The nanocatalyst showed excellent product yields, easy magnetic recovery, and was successfully recycled 8 times without significant loss of activity. Additionally, it exhibited low cytotoxicity against lung cancer cells while reducing cell viability dose-dependently.
This work describes an eco-friendly approach for in situ immobilization of Cu nanoparticles on the surface of lignin modified Fe3O4 nanoparticles, without using any toxic reducing and capping agents. The structure, morphology, and physicochemical properties were characterized by various analytical techniques such as Fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP) and vibrating sample magnetometer (VSM). The Fe3O4/Lignin/Cu NPs was proven to be highly efficient nanocatalyst for reduction of nitroarenes. The reaction was performed in water medium and excellent yields of the products were achieved. The nanocatalyst was easily magnetically recov ered and recycled 8 times without any significant loss of catalytic activity. While studying the biological activity, cell viability of Fe3O4/Lignin/Cu NPs was very low against A549 lung cancer cells without any cytotoxicity on the normal cell line. The viability of lung cancer cell line reduced dose dependently in the presence of Fe3O4/Lignin/Cu nanocomposite. The IC50 of Fe3O4/Lignin/Cu nanocomposite was32 mu g/mL against A549 cell line. (C) 2021 Published by Elsevier B.V. on behalf of King Saud University.
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