Ligand-Enabled Copper(I)-Catalyzed Asymmetric Radical C(sp(3))-C Cross-Coupling Reactions

The first-row transition-metal-catalyzed asymmetric C- (sp(3))-C cross-coupling represents a powerful approach in the expedient synthesis of enantioenriched molecules. Recently, a series of chiral copper catalysts have been designed to promote a variety of asymmetric radical C(sp(3))-C cross-coupling reactions with high efficiency and enantioselectivity. The key to success is the design of chiral ligands to initiate the reaction and achieve enantiocontrol over the highly reactive prochiral alkyl radical species. This Perspective will discuss the impressive advances and provide an outlook on the direction of further development.

Automated summary

Transition-metal-catalyzed asymmetric C-(sp(3))-C cross-coupling is an efficient method for the rapid synthesis of enantioenriched molecules. Chiral copper catalysts have been designed to promote a variety of asymmetric radical C(sp(3))-C cross-coupling reactions with high efficiency and enantioselectivity. The key to success lies in the design of chiral ligands to initiate the reaction and achieve enantiocontrol over the highly reactive prochiral alkyl radical species.