4.8 Article

Development of a model-inference system for estimating epidemiological characteristics of SARS-CoV-2 variants of concern

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Estimating the infection-fatality risk of SARS-CoV-2 in New York City during the spring 2020 pandemic wave: a model-based analysis

Wan Yang et al.

Summary: This study estimated the infection-fatality risk of COVID-19 in New York City, showing that the risk for individuals aged 65 and above is significantly higher than younger age groups.

LANCET INFECTIOUS DISEASES (2021)

Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.
Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.
Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

Article Multidisciplinary Sciences

Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa

Jane Alexandra Shaw et al.

Summary: In Cape Town, South Africa, there is a high seroprevalence of SARS-CoV-2 antibodies, particularly among those of lower socioeconomic status. Nearly half of cases are asymptomatic, with seropositivity being significantly associated with living conditions, low-income areas, and low-paying occupations.

PLOS ONE (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Markus Hoffmann et al.

Summary: The emerging SARS-CoV-2 variants may exhibit resistance to existing neutralizing antibodies and treatments, which could have significant implications for pandemic containment efforts.
Article Biochemistry & Molecular Biology

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

Delphine Planas et al.

Summary: The ability of convalescent sera from individuals with coronavirus disease 2019 and those vaccinated with BNT162b2 to neutralize SARS-CoV-2 variants B1.1.7 and B.1.351 decreases, but increases after two vaccine doses. The study found that the B.1.1.7 and B.1.351 variants may have acquired partial resistance to neutralizing antibodies generated by natural infection or vaccination, particularly in individuals with low antibody levels. This suggests that the B.1.351 variant may pose a greater risk of infection in immunized individuals.

NATURE MEDICINE (2021)

Letter Medicine, General & Internal

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

Laith J. Abu-Raddad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant

V. Shinde et al.

Summary: The NVX-CoV2373 vaccine showed efficacy in preventing Covid-19, with higher vaccine efficacy observed among HIV-negative participants. Most infections were caused by the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Resurgence of SARS-CoV-2: Detection by community viral surveillance

Steven Riley et al.

Summary: Monitoring the SARS-CoV-2 pandemic in England using a national representative surveillance program based on self-administered swab results from over 594,000 individuals tested between May and the beginning of September 2020 revealed a decline followed by a resurgence in cases, indicative of a second wave. The study suggests that representative community sampling can provide valuable insights for public health responses, especially during periods of low prevalence.

SCIENCE (2021)

Article Psychology, Biological

A global database of COVID-19 vaccinations

Edouard Mathieu et al.

Summary: An effective rollout of COVID-19 vaccines is crucial in ending the pandemic, and Our World in Data's vaccination dataset tracks the progress and scale of vaccine distribution globally, aiding policymakers and researchers in understanding the global vaccination efforts.

NATURE HUMAN BEHAVIOUR (2021)

Article Biochemical Research Methods

Modeling influenza seasonality in the tropics and subtropics

Haokun Yuan et al.

Summary: Climate drivers such as humidity and temperature have a significant impact on influenza transmission in subtropical regions, with a simple model effectively replicating epidemic patterns observed in Hong Kong by quantifying the bimodal effect of absolute humidity on transmission and the nonlinear relationship with temperature. Shorter immunity periods also play a crucial role in approximating the co-circulation of influenza virus (sub)types at the population level. The study's findings are consistent with laboratory studies on influenza survival and transmission dynamics under different humidity and temperature levels.

PLOS COMPUTATIONAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Effectiveness of non-pharmaceutical interventions to contain COVID-19: a case study of the 2020 spring pandemic wave in New York City

Wan Yang et al.

Summary: The study found that lockdown-like measures and universal masking significantly reduced COVID-19 transmission, especially for the 65+ age group. However, using face masks alone may not be sufficient to control the spread of the virus.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2021)

Letter Infectious Diseases

An interactive web-based dashboard to track COVID-19 in real time

Ensheng Dong et al.

LANCET INFECTIOUS DISEASES (2020)

Article Biochemical Research Methods

Dynamic interactions of influenza viruses in Hong Kong during 1998-2018

Wan Yang et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

Article Public, Environmental & Occupational Health

SARS-CoV-2 antibody prevalence in Brazil: results from two successive nationwide serological household surveys

Pedro C. Hallal et al.

LANCET GLOBAL HEALTH (2020)