4.8 Article

Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

Journal

NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -

Publisher

NATURE RESEARCH
DOI: 10.1038/s41467-021-23069-0

Keywords

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Funding

  1. National Natural Science Foundation of China [82071158, 81900977, 51925308, 51872336]
  2. Guangdong Basic and Applied Basic Research Foundation [2019A1515010592, 2020A1515011426, 2021A1515010364]
  3. Guangzhou Science and Technology Planning Project [201904010150]
  4. Guangdong Financial Fund for High-Caliber Hospital Construction [174-2018-XMZC-0001-03-0125/D-19]
  5. Leading Scientific, Technical and Innovation Talents of Guangdong Special Support Programme [2017TX04C248]

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Ti implantation infection is a major threat to the success of dental implants, with coatings on Ti surfaces losing their antibacterial efficacy rapidly. The N-halamine polymeric coating presented in this study demonstrates long-lasting renewable antibacterial efficacy, providing a promising solution for prevention and treatment of peri-implant infection.
Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12-16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection. Infection is a major problem for dental implants with current antibacterial coatings losing efficacy quickly. Here, the authors report on the N-halamine polymeric coating of titanium implants to create a long-lasting renewable antibacterial layer and demonstrate application in vivo.

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