Related references
Note: Only part of the references are listed.Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC
Yaqun Zhang et al.
PROSTATE CANCER AND PROSTATIC DISEASES (2020)
Variable Mutations at the p53-R273 Oncogenic Hotspot Position Leads to Altered Properties
Ankush Garg et al.
BIOPHYSICAL JOURNAL (2020)
Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity
L. Palanikumar et al.
BIOCHEMISTRY (2020)
pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics
L. Palanikumar et al.
COMMUNICATIONS BIOLOGY (2020)
Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity
Anja Henning-Knechtel et al.
CELL REPORTS PHYSICAL SCIENCE (2020)
The multiple mechanisms that regulate p53 activity and cell fate
Antonina Hafner et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
Joan Montero et al.
NATURE COMMUNICATIONS (2019)
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2019)
Bifunctional ligand design for modulating mutant p53 aggregation in cancer
Jessica J. Miller et al.
CHEMICAL SCIENCE (2019)
Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function
Sunil Kumar et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Therapeutic developments in pancreatic cancer: current and future perspectives
John P. Neoptolemos et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)
African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat
Jason Pinger et al.
NATURE MICROBIOLOGY (2018)
Treating p53 Mutant Aggregation-Associated Cancer
Mathumai Kanapathipillai
CANCERS (2018)
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2018)
Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution
Christian D. Kelstrup et al.
JOURNAL OF PROTEOME RESEARCH (2018)
Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
Jin-Long Gao et al.
NATURE COMMUNICATIONS (2018)
Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer
Jerson L. Silva et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Targeting mutant p53 for efficient cancer therapy
Vladimir J. N. Bykov et al.
NATURE REVIEWS CANCER (2018)
Why are there hotspot mutations in the TP53 gene in human cancers?
Evan H. Baugh et al.
CELL DEATH AND DIFFERENTIATION (2018)
The START App: a web-based RNAseq analysis and visualization resource
Jonathan W. Nelson et al.
BIOINFORMATICS (2017)
Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer
Charles J. Bowerman et al.
NANO LETTERS (2017)
Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells
Abiy D. Woldetsadik et al.
FASEB JOURNAL (2017)
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
Fatima Ardito et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)
α-Helix Mimetics as Modulators of Aβ Self-Assembly
Sunil Kumar et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Oogenesis and reproductive investment of Atlantic herring are functions of not only present but long-ago environmental influences as well
Thassya C. dos Santos Schmidt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
A matter of time - How transient transcription factor interactions create dynamic gene regulatory networks
Joseph Swift et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2017)
Intrinsic Differences in Backbone Dynamics between Wild Type and DNA-Contact Mutants of the p53 DNA Binding Domain Revealed by Nuclear Magnetic Resonance Spectroscopy
Juhi A. Rasquinha et al.
BIOCHEMISTRY (2017)
p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis
Saikat Ghosh et al.
CELL DEATH AND DIFFERENTIATION (2017)
Putting p53 in Context
Edward R. Kastenhuber et al.
CELL (2017)
Structural Studies of Amyloid Proteins at the Molecular Level
David S. Eisenberg et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
Andreas C. Joerger et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas
Alice Soragni et al.
CANCER CELL (2016)
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
Ansar Karimian et al.
DNA REPAIR (2016)
TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data
Liacine Bouaoun et al.
HUMAN MUTATION (2016)
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Jiandong Chen
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
p53 in the DNA-Damage-Repair Process
Ashley B. Williams et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Influence of Human p53 on Plant Development
Huimin Ma et al.
PLOS ONE (2016)
Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics
Sunil Kumar et al.
CHEMISTRY & BIOLOGY (2015)
ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap
Tauno Metsalu et al.
NUCLEIC ACIDS RESEARCH (2015)
Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation
Oleg V. Kulikov et al.
TETRAHEDRON LETTERS (2015)
Structure based aggregation studies reveal the presence of helix-rich intermediate during alpha-Synuclein aggregation
Dhiman Ghosh et al.
SCIENTIFIC REPORTS (2015)
The Molecular Signatures Database Hallmark Gene Set Collection
Arthur Liberzon et al.
CELL SYSTEMS (2015)
Investigating the Intrinsic Aggregation Potential of Evolutionarily Conserved Segments in p53
Saikat Ghosh et al.
BIOCHEMISTRY (2014)
α-Helix mimetics: Outwards and upwards
Madura K. P. Jayatunga et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Drugging the p53 pathway: understanding the route to clinical efficacy
Khoo Kian Hoe et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Tracking cancer drugs in living cells by thermal profiling of the proteome
Mikhail M. Savitski et al.
SCIENCE (2014)
Prion-like aggregation of mutant p53 in cancer
Jerson L. Silva et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
GENOME BIOLOGY (2014)
Unravelling mechanisms of p53-mediated tumour suppression
Kathryn T. Bieging et al.
NATURE REVIEWS CANCER (2014)
Noxa and cancer therapy Tuning up the mitochondrial death machinery in response to chemotherapy
Marie-Christine Albert et al.
MOLECULAR & CELLULAR ONCOLOGY (2014)
Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitro and in Vivo
Zhong Luo et al.
ACS NANO (2013)
Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines
Beatriz Garcia-Castro et al.
BMC CANCER (2013)
An Alternative Approach in GatewayA® Cloning when the Bacterial Antibiotic Selection Cassettes of the Entry Clone and Destination Vector are the Same
Kamal Kumar et al.
MOLECULAR BIOTECHNOLOGY (2013)
Inhibition of α-helix-mediated protein-protein interactions using designed molecules
Valeria Azzarito et al.
NATURE CHEMISTRY (2013)
Using chemical shift perturbation to characterise ligand binding
Mike P. Williamson
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2013)
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Daniel Martinez Molina et al.
SCIENCE (2013)
Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis
Jeyran Shahbazi et al.
Frontiers in Genetics (2013)
From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation
Samuel I. A. Cohen et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
First-order rate-determining aggregation mechanism of p53 and its implications
GuoZhen Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Highly neurotoxic monomeric α-helical prion protein
Minghai Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A practical guide to evaluating colocalization in biological microscopy
Kenneth W. Dunn et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
Colleen A. Brady et al.
CELL (2011)
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
Jie Xu et al.
NATURE CHEMICAL BIOLOGY (2011)
PROTEIN AGGREGATION p53 succumbs to peer pressure
Mazin Magzoub et al.
NATURE CHEMICAL BIOLOGY (2011)
Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer
S. Takano et al.
BRITISH JOURNAL OF CANCER (2010)
Disrupting protein-protein interactions with non-peptidic, small molecule α-helix mimetics
Christopher G. Cummings et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
Pancreatic Cancer
Manuel Hidalgo
NEW ENGLAND JOURNAL OF MEDICINE (2010)
The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage
J-H Lee et al.
ONCOGENE (2010)
The Tumor Suppressor p53: From Structures to Drug Discovery
Andreas C. Joerger et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Walls around tumours-why plants do not develop cancer
John H. Doonan et al.
NATURE REVIEWS CANCER (2010)
Protein Sequences Encode Safeguards Against Aggregation
Joke Reumers et al.
HUMAN MUTATION (2009)
Tumor-specific protein human galectin-1 interacts with anticancer agents
Sabato D'Auria et al.
MOLECULAR BIOSYSTEMS (2009)
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
Da Wei Huang et al.
NUCLEIC ACIDS RESEARCH (2009)
p53 represses c-Myc through induction of the tumor suppressor miR-145
Mohit Sachdeva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Tumor Suppressive Functions of p53
Jack T. Zilfou et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
p21 in cancer: intricate networks and multiple activities
Tarek Abbas et al.
NATURE REVIEWS CANCER (2009)
A role for helical intermediates in amyloid formation by natively unfolded polypeptides?
Andisheh Abedini et al.
PHYSICAL BIOLOGY (2009)
Growth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expression
Samuel Godar et al.
CELL (2008)
Molecular chaperones as regulators of cell death
A. Hishiya et al.
ONCOGENE (2008)
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells
Muhammad Emaduddin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The potential role of Akt phosphorylation in human cancers
J. Cicenas
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2008)
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
C. Welch et al.
ONCOGENE (2007)
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
G. Selivanova et al.
ONCOGENE (2007)
A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
J. Yu et al.
CELL DEATH AND DIFFERENTIATION (2007)
Apoptosis: A review of programmed cell death
Susan Elmore
TOXICOLOGIC PATHOLOGY (2007)
The p53 tumor suppressor participates in multiple cell cycle checkpoints
Luciana E. Giono et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains
Hwee Ching Ang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Solution structure of p53 core domain:: Structural basis for its instability
JMP Cañadillas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer
Y Higashimoto et al.
BIOCHEMISTRY (2006)
Highly selective enrichment of phosphorylated peptides using titanium dioxide
Tine E. Thingholm et al.
NATURE PROTOCOLS (2006)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
A Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Prediction of aggregation-prone and aggregation-susceptible regions in proteins associated with neurodegenerative diseases
AP Pawar et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
The coordinate regulation of the p53 and rnTOR pathways in cells
ZH Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The p53 pathway: positive and negative feedback loops
SL Harris et al.
ONCOGENE (2005)
Molecular basis for the RIN4 negative regulation of RPS2 disease resistance
B Day et al.
PLANT CELL (2005)
Morphological characterization of thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Aβ immunotherapy on their clearance
T Bussière et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
DA Altomare et al.
ONCOGENE (2004)
Fibrillar aggregates of the tumor suppressor p53 core domain
D Ishimaru et al.
BIOCHEMISTRY (2003)
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed et al.
SCIENCE (2003)
PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry
B Ma et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2003)
Spatial repression of PCNA by p53 during kidney development
Z Saifudeen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
MD Kaeser et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Regulation of PTEN transcription by p53
V Stambolic et al.
MOLECULAR CELL (2001)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)