4.8 Article

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Related references

Note: Only part of the references are listed.
Article Oncology

Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC

Yaqun Zhang et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2020)

Article Chemistry, Multidisciplinary

Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

Anja Henning-Knechtel et al.

CELL REPORTS PHYSICAL SCIENCE (2020)

Review Cell Biology

The multiple mechanisms that regulate p53 activity and cell fate

Antonina Hafner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Joan Montero et al.

NATURE COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Bifunctional ligand design for modulating mutant p53 aggregation in cancer

Jessica J. Miller et al.

CHEMICAL SCIENCE (2019)

Article Chemistry, Multidisciplinary

Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function

Sunil Kumar et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Gastroenterology & Hepatology

Therapeutic developments in pancreatic cancer: current and future perspectives

John P. Neoptolemos et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Oncology

Treating p53 Mutant Aggregation-Associated Cancer

Mathumai Kanapathipillai

CANCERS (2018)

Article Biochemical Research Methods

Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution

Christian D. Kelstrup et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Review Chemistry, Multidisciplinary

Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer

Jerson L. Silva et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

Review Oncology

Targeting mutant p53 for efficient cancer therapy

Vladimir J. N. Bykov et al.

NATURE REVIEWS CANCER (2018)

Review Biochemistry & Molecular Biology

Why are there hotspot mutations in the TP53 gene in human cancers?

Evan H. Baugh et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Biochemical Research Methods

The START App: a web-based RNAseq analysis and visualization resource

Jonathan W. Nelson et al.

BIOINFORMATICS (2017)

Article Chemistry, Multidisciplinary

Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer

Charles J. Bowerman et al.

NANO LETTERS (2017)

Article Biochemistry & Molecular Biology

Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Abiy D. Woldetsadik et al.

FASEB JOURNAL (2017)

Review Medicine, Research & Experimental

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy

Fatima Ardito et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Chemistry, Multidisciplinary

α-Helix Mimetics as Modulators of Aβ Self-Assembly

Sunil Kumar et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Multidisciplinary Sciences

Oogenesis and reproductive investment of Atlantic herring are functions of not only present but long-ago environmental influences as well

Thassya C. dos Santos Schmidt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

A matter of time - How transient transcription factor interactions create dynamic gene regulatory networks

Joseph Swift et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2017)

Article Biochemistry & Molecular Biology

p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis

Saikat Ghosh et al.

CELL DEATH AND DIFFERENTIATION (2017)

Review Biochemistry & Molecular Biology

Putting p53 in Context

Edward R. Kastenhuber et al.

Review Biochemistry & Molecular Biology

Structural Studies of Amyloid Proteins at the Molecular Level

David S. Eisenberg et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)

Review Biochemistry & Molecular Biology

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

Andreas C. Joerger et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Article Genetics & Heredity

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

Liacine Bouaoun et al.

HUMAN MUTATION (2016)

Article Medicine, Research & Experimental

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

Jiandong Chen

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Article Medicine, Research & Experimental

p53 in the DNA-Damage-Repair Process

Ashley B. Williams et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Article Multidisciplinary Sciences

Influence of Human p53 on Plant Development

Huimin Ma et al.

PLOS ONE (2016)

Article Biochemistry & Molecular Biology

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

Tauno Metsalu et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Chemistry, Organic

Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation

Oleg V. Kulikov et al.

TETRAHEDRON LETTERS (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Biochemistry & Molecular Biology

Investigating the Intrinsic Aggregation Potential of Evolutionarily Conserved Segments in p53

Saikat Ghosh et al.

BIOCHEMISTRY (2014)

Article Chemistry, Medicinal

α-Helix mimetics: Outwards and upwards

Madura K. P. Jayatunga et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Review Biotechnology & Applied Microbiology

Drugging the p53 pathway: understanding the route to clinical efficacy

Khoo Kian Hoe et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Multidisciplinary Sciences

Tracking cancer drugs in living cells by thermal profiling of the proteome

Mikhail M. Savitski et al.

SCIENCE (2014)

Review Biochemistry & Molecular Biology

Prion-like aggregation of mutant p53 in cancer

Jerson L. Silva et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Oncology

Unravelling mechanisms of p53-mediated tumour suppression

Kathryn T. Bieging et al.

NATURE REVIEWS CANCER (2014)

Review Oncology

Noxa and cancer therapy Tuning up the mitochondrial death machinery in response to chemotherapy

Marie-Christine Albert et al.

MOLECULAR & CELLULAR ONCOLOGY (2014)

Article Oncology

Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines

Beatriz Garcia-Castro et al.

BMC CANCER (2013)

Article Cell Biology

mTORC1 and p53 Clash of the gods?

Paul Hasty et al.

CELL CYCLE (2013)

Review Chemistry, Multidisciplinary

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

Valeria Azzarito et al.

NATURE CHEMISTRY (2013)

Article Physics, Atomic, Molecular & Chemical

Using chemical shift perturbation to characterise ligand binding

Mike P. Williamson

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2013)

Article Multidisciplinary Sciences

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Daniel Martinez Molina et al.

SCIENCE (2013)

Article Genetics & Heredity

Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis

Jeyran Shahbazi et al.

Frontiers in Genetics (2013)

Review Biochemistry & Molecular Biology

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

Samuel I. A. Cohen et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

First-order rate-determining aggregation mechanism of p53 and its implications

GuoZhen Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Highly neurotoxic monomeric α-helical prion protein

Minghai Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cell Biology

A practical guide to evaluating colocalization in biological microscopy

Kenneth W. Dunn et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Article Biochemistry & Molecular Biology

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Colleen A. Brady et al.

Article Biochemistry & Molecular Biology

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Jie Xu et al.

NATURE CHEMICAL BIOLOGY (2011)

News Item Biochemistry & Molecular Biology

PROTEIN AGGREGATION p53 succumbs to peer pressure

Mazin Magzoub et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Disrupting protein-protein interactions with non-peptidic, small molecule α-helix mimetics

Christopher G. Cummings et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2010)

Review Medicine, General & Internal

Pancreatic Cancer

Manuel Hidalgo

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage

J-H Lee et al.

ONCOGENE (2010)

Article Cell Biology

The Tumor Suppressor p53: From Structures to Drug Discovery

Andreas C. Joerger et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Review Oncology

Walls around tumours-why plants do not develop cancer

John H. Doonan et al.

NATURE REVIEWS CANCER (2010)

Article Genetics & Heredity

Protein Sequences Encode Safeguards Against Aggregation

Joke Reumers et al.

HUMAN MUTATION (2009)

Article Biochemistry & Molecular Biology

Tumor-specific protein human galectin-1 interacts with anticancer agents

Sabato D'Auria et al.

MOLECULAR BIOSYSTEMS (2009)

Editorial Material Biochemistry & Molecular Biology

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Da Wei Huang et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

p53 represses c-Myc through induction of the tumor suppressor miR-145

Mohit Sachdeva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell Biology

Tumor Suppressive Functions of p53

Jack T. Zilfou et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

Review Oncology

p21 in cancer: intricate networks and multiple activities

Tarek Abbas et al.

NATURE REVIEWS CANCER (2009)

Article Biochemistry & Molecular Biology

A role for helical intermediates in amyloid formation by natively unfolded polypeptides?

Andisheh Abedini et al.

PHYSICAL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Molecular chaperones as regulators of cell death

A. Hishiya et al.

ONCOGENE (2008)

Article Multidisciplinary Sciences

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells

Muhammad Emaduddin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biotechnology & Applied Microbiology

The potential role of Akt phosphorylation in human cancers

J. Cicenas

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2008)

Review Biochemistry & Molecular Biology

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

G. Selivanova et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells

J. Yu et al.

CELL DEATH AND DIFFERENTIATION (2007)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

Review Cell Biology

The p53 tumor suppressor participates in multiple cell cycle checkpoints

Luciana E. Giono et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains

Hwee Ching Ang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Solution structure of p53 core domain:: Structural basis for its instability

JMP Cañadillas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemical Research Methods

Highly selective enrichment of phosphorylated peptides using titanium dioxide

Tine E. Thingholm et al.

NATURE PROTOCOLS (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Prediction of aggregation-prone and aggregation-susceptible regions in proteins associated with neurodegenerative diseases

AP Pawar et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

The coordinate regulation of the p53 and rnTOR pathways in cells

ZH Feng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

The p53 pathway: positive and negative feedback loops

SL Harris et al.

ONCOGENE (2005)

Article Biochemistry & Molecular Biology

Molecular basis for the RIN4 negative regulation of RPS2 disease resistance

B Day et al.

PLANT CELL (2005)

Article Biochemistry & Molecular Biology

Fibrillar aggregates of the tumor suppressor p53 core domain

D Ishimaru et al.

BIOCHEMISTRY (2003)

Article Biochemical Research Methods

PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry

B Ma et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2003)

Article Physiology

Spatial repression of PCNA by p53 during kidney development

Z Saifudeen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)

Article Multidisciplinary Sciences

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

MD Kaeser et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Oncology

Rescuing the function of mutant p53

AN Bullock et al.

NATURE REVIEWS CANCER (2001)

Article Biochemistry & Molecular Biology

Regulation of PTEN transcription by p53

V Stambolic et al.

MOLECULAR CELL (2001)