4.8 Article

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

Jordan R. Becker et al.

Summary: The study reveals that BRCA1-BARD1 complexes coordinate the choice of DNA double-strand break (DSB) repair pathway by sensing DNA-damage-dependent histone post-translation modification states, promoting homologous recombination activities. BARD1 binds nucleosomes through multivalent interactions and facilitates the recruitment of BRCA1 to DSB sites.

NATURE (2021)

Article Biochemistry & Molecular Biology

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Elsa Callen et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci

Jekaterina Vohhodina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

BRCA1 Mutational Complementation Induces Synthetic Viability

Joseph Nacson et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

Dali Zong et al.

MOLECULAR CELL (2019)

Article Cell Biology

H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

Kyosuke Nakamura et al.

NATURE CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

Yifan Wang et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms

Mikaela D. Stewart et al.

PROTEIN SCIENCE (2017)

Article Biochemistry & Molecular Biology

53BP1 ablation rescues genomic instability in mice expressing RING-less' BRCA1

Minxing Li et al.

EMBO REPORTS (2016)

Article Medicine, Research & Experimental

RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance

Yifan Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, Research & Experimental

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

Rinske Drost et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

Ruth M. Densham et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage

Nam Soo Lee et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

Ruth M. Densham et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Tina Thorslund et al.

NATURE (2015)

Article Cell Biology

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

Andres Cruz-Garcia et al.

CELL REPORTS (2014)

Article Multidisciplinary Sciences

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

Neil Johnson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

Francesca Mattiroli et al.

Review Oncology

BRCA1 and BRCA2: different roles in a common pathway of genome protection

Rohini Roy et al.

NATURE REVIEWS CANCER (2012)

Review Cell Biology

BRCA1 and its toolbox for the maintenance of genome integrity

Michael S. Y. Huen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Feng Zhang et al.

CURRENT BIOLOGY (2009)

Article Multidisciplinary Sciences

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Joanna R. Morris et al.

NATURE (2009)

Article Multidisciplinary Sciences

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Shirley M. H. Sy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

Bin Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Nadine K. Kolas et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

Hongtae Kim et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

Bijan Sobhian et al.

SCIENCE (2007)

Review Cell Biology

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

R Baer et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2002)

Article Multidisciplinary Sciences

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

V Joukov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)