Neuronal variability reflects probabilistic inference tuned to natural image statistics

Neuronal activity in sensory cortex fluctuates over time and across repetitions of the same input. This variability is often considered detrimental to neural coding. The theory of neural sampling proposes instead that variability encodes the uncertainty of perceptual inferences. In primary visual cortex (V1), modulation of variability by sensory and non-sensory factors supports this view. However, it is unknown whether V1 variability reflects the statistical structure of visual inputs, as would be required for inferences correctly tuned to the statistics of the natural environment. Here we combine analysis of image statistics and recordings in macaque V1 to show that probabilistic inference tuned to natural image statistics explains the widely observed dependence between spike count variance and mean, and the modulation of V1 activity and variability by spatial context in images. Our results show that the properties of a basic aspect of cortical responses-their variability-can be explained by a probabilistic representation tuned to naturalistic inputs. The neural sampling theory suggests that neuronal variability encodes the uncertainty of probabilistic inferences. This paper shows that response variability in primary visual cortex reflects the statistical structure of visual inputs, as required for inferences correctly tuned to the statistics of the natural environment.

Automated summary

This study combines analysis of image statistics and recordings in macaque V1 to demonstrate that probabilistic inference tuned to natural image statistics can explain the relationship between spike count variance and mean as well as the modulation of V1 activity and variability by spatial context in images. The results show that variability in cortical responses can be explained by a probabilistic representation tuned to naturalistic inputs, supporting the neural sampling theory that neuronal variability encodes the uncertainty of probabilistic inferences. This paper highlights that response variability in primary visual cortex reflects the statistical structure of visual inputs, which is essential for inferences correctly tuned to the statistics of the natural environment.