4.8 Article

A platform for on-the-complex annulation reactions with transient aryne intermediates

Journal

NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -

Publisher

NATURE RESEARCH
DOI: 10.1038/s41467-021-23970-8

Keywords

-

Funding

  1. University of California, Los Angeles
  2. NIH-NIGMS [R01 GM123299, R35 GM139593]
  3. Foote Family
  4. Trueblood Family
  5. NSF [CHE-1048804]
  6. NIH NCRR [S10RR025631]

Ask authors/readers for more resources

The study presents a versatile platform for on-the-complex annulation reactions using transient aryne intermediates to access pi-extended polypyridyl complexes, providing an effective strategy for annulating organometallic complexes and accessing complex metal-ligand scaffolds.
Organometallic complexes are ubiquitous in chemistry and biology. Whereas their preparation has historically relied on ligand synthesis followed by coordination to metal centers, the ability to efficiently diversify their structures remains a synthetic challenge. A promising yet underdeveloped strategy involves the direct manipulation of ligands that are already bound to a metal center, also known as chemistry-on-the-complex. Herein, we introduce a versatile platform for on-the-complex annulation reactions using transient aryne intermediates. In one variant, organometallic complexes undergo transition metal-catalyzed annulations with in situ generated arynes to form up to six new carbon-carbon bonds. In the other variant, an organometallic complex bearing a free aryne is generated and intercepted in cycloaddition reactions to access unique scaffolds. Our studies, centered around privileged polypyridyl metal complexes, provide an effective strategy to annulate organometallic complexes and access complex metal-ligand scaffolds, while furthering the synthetic utility of strained intermediates in chemical synthesis. Organometallic complexes have numerous applications in chemistry and biology, but diversification of their structures is synthetically challenging. Here, the authors report a versatile platform for on-the-complex annulation reactions using transient aryne intermediates to access pi-extended polypyridyl complexes.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available