Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41467-021-24346-8
Keywords
-
Categories
Funding
- Austrian Science Foundation (FWF) [P30404-B29]
- HFSP postdoctoral fellowship [LT000809/2012-L]
- Lise Meitner FWF fellowship [M1140-B17]
- Austrian Science Fund (FWF) [P30404] Funding Source: Austrian Science Fund (FWF)
Ask authors/readers for more resources
Animals rely on concentration-dependent interpretation of morphogen signals for body axis patterning, while the ancient axis patterning system across animal phyla involves beta-catenin signaling. Differences in patterning logic exist between protostomes and deuterostomes, but a common regulatory logic of beta-catenin-dependent patterning is observed in Nematostella and deuterostomes. This suggests a shared evolutionary origin of these processes and the equivalence of cnidarian oral-aboral and bilaterian posterior-anterior body axes.
In animals, body axis patterning is based on the concentration-dependent interpretation of graded morphogen signals, which enables correct positioning of the anatomical structures. The most ancient axis patterning system acting across animal phyla relies on beta -catenin signaling, which directs gastrulation, and patterns the main body axis. However, within Bilateria, the patterning logic varies significantly between protostomes and deuterostomes. To deduce the ancestral principles of beta -catenin-dependent axial patterning, we investigate the oral-aboral axis patterning in the sea anemone Nematostella-a member of the bilaterian sister group Cnidaria. Here we elucidate the regulatory logic by which more orally expressed beta -catenin targets repress more aborally expressed beta -catenin targets, and progressively restrict the initially global, maternally provided aboral identity. Similar regulatory logic of beta -catenin-dependent patterning in Nematostella and deuterostomes suggests a common evolutionary origin of these processes and the equivalence of the cnidarian oral-aboral and the bilaterian posterior-anterior body axes. The authors show in Nematostella that the more orally expressed beta -catenin targets repress the more aborally expressed beta -catenin targets, thus patterning the oral-aboral axis. This likely represents the common mechanism of beta -catenin-dependent axial patterning shared by Cnidaria and Bilateria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available