Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-25595-3
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Funding
- National Institutes of Health (NIH) [R01NS034467, R01AG023084, R01AG039452, R01NS100459, R01NS117827, P01AG052350, P30AG06653]
- Foundation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease [16 CVD 05]
- Cure Alzheimer's Fund
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Microglia play a crucial role in regulating capillary vascular tone and blood flow, with a recently identified signaling mechanism attracting and maintaining them at the capillary wall.
Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.
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