Related references
Note: Only part of the references are listed.Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors
Hannes Schihada et al.
BIOSENSORS & BIOELECTRONICS (2021)
Molecular Pharmacology of Class F Receptor Activation
Pawel Kozielewicz et al.
MOLECULAR PHARMACOLOGY (2020)
A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine
Pawel Kozielewicz et al.
MOLECULAR PHARMACOLOGY (2020)
Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches
Oliver Fleetwood et al.
BIOCHEMISTRY (2020)
Structural insight into small molecule action on Frizzleds
Pawel Kozielewicz et al.
NATURE COMMUNICATIONS (2020)
Impact of GPCR Structures on Drug Discovery
Miles Congreve et al.
CELL (2020)
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled
Janine Wesslowski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin
Andreyah L. Pope et al.
STRUCTURE (2020)
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
Naotaka Tsutsumi et al.
ELIFE (2020)
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Xiaofeng Qi et al.
NATURE CHEMICAL BIOLOGY (2020)
Agonist-induced formation of unproductive receptor-G12 complexes
Najeah Okashah et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
Shane C. Wright et al.
NATURE COMMUNICATIONS (2019)
Biochemical mechanisms of vertebrate hedgehog signaling
Jennifer H. Kong et al.
DEVELOPMENT (2019)
WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins
Carl-Fredrik Bowin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
Xiaofeng Qi et al.
NATURE (2019)
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Ishan Deshpande et al.
NATURE (2019)
Wnt signaling in development and tissue homeostasis
Zachary Steinhart et al.
DEVELOPMENT (2018)
Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells
Qingwen Wan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
A molecular mechanism for Wnt ligand-specific signaling
Marie Eubelen et al.
SCIENCE (2018)
The Molecular Basis of G Protein-Coupled Receptor Activation
William I. Weis et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)
Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment
Jana Valnohova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Crystal structure of the Frizzled 4 receptor in a ligand-free state
Shifan Yang et al.
NATURE (2018)
Frizzleds as GPCRs - More Conventional Than We Thought!
Gunnar Schulte et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
FZD(5) is a G alpha(q)-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
Shane C. Wright et al.
SCIENCE SIGNALING (2018)
GPCR Dynamics: Structures in Motion
Naomi R. Latorraca et al.
CHEMICAL REVIEWS (2017)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
Benjamin R. Myers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Mini-G proteins: Novel tools for studying GPCRs in their active conformation
Rony Nehme et al.
PLOS ONE (2017)
Hedgehog Signaling: From Basic Biology to Cancer Therapy
Fujia Wu et al.
CELL CHEMICAL BIOLOGY (2017)
The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes
G. C. P. van Zundert et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
Melissa V. Gammons et al.
MOLECULAR CELL (2016)
Structural basis of Smoothened regulation by its extracellular domains
Eamon F. X. Byrne et al.
NATURE (2016)
Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity
Michaela B. C. Kilander et al.
CELLULAR SIGNALLING (2014)
Structured and disordered facets of the GPCR fold
A. J. Venkatakrishnan et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2014)
Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
Michaela B. C. Kilander et al.
FASEB JOURNAL (2014)
Allosteric sodium in class A GPCR signaling
Vsevolod Katritch et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs
Chong Wang et al.
NATURE COMMUNICATIONS (2014)
Smoothened Is a Fully Competent Activator of the Heterotrimeric G Protein Gi
Feng Shen et al.
MOLECULAR PHARMACOLOGY (2013)
Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle
Julia von Maltzahn et al.
NATURE CELL BIOLOGY (2012)
OPM database and PPM web server: resources for positioning of proteins in membranes
Mikhail A. Lomize et al.
NUCLEIC ACIDS RESEARCH (2012)
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Soren G. F. Rasmussen et al.
NATURE (2011)
Crystal structure of the β2 adrenergic receptor-Gs protein complex
Soren G. F. Rasmussen et al.
NATURE (2011)
fpocket: online tools for protein ensemble pocket detection and tracking
Peter Schmidtke et al.
NUCLEIC ACIDS RESEARCH (2010)
International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
Gunnar Schulte
PHARMACOLOGICAL REVIEWS (2010)
CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes
Sunhwan Jo et al.
BIOPHYSICAL JOURNAL (2009)
Fpocket: An open source platform for ligand pocket detection
Vincent Le Guilloux et al.
BMC BIOINFORMATICS (2009)
Crystal structure of opsin in its G-protein-interacting conformation
Patrick Scheerer et al.
NATURE (2008)
Crystal structure of the ligand-free G-protein-coupled receptor opsin
Jung Hee Park et al.
NATURE (2008)
Clustal W and clustal X version 2.0
M. A. Larkin et al.
BIOINFORMATICS (2007)
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15
Christelle Masdeu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
Richard A. Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Activation of heterotrimeric G proteins by smoothened
Natalia A. Riobo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
International Union of Pharmacology. XLVI. G protein-coupled receptor list
SM Foord et al.
PHARMACOLOGICAL REVIEWS (2005)
The human frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt•β-Catenin signaling cascade
T Golan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
TA Halgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Development and testing of a general amber force field
JM Wang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
The Wnt signaling pathway in development and disease
CY Logan et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)
HADDOCK: A protein-protein docking approach based on biochemical or biophysical information
C Dominguez et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation
A Jakalian et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2002)
Small molecule modulation of Smoothened activity
JK Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Smoothened activates Gαi-mediated signaling in frog melanophores
DL DeCamp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
