Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-24838-7
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Funding
- National Key R&D Program of China [2018YFE0201701, 2018YFA0209401]
- National Natural Science Foundation of China [22075049, 21875043, 21701027, 21733003, 21905052, 51961145403, 22088101]
- Key Basic Research Program of Science and Technology Commission of Shanghai Municipality [17JC1400100]
- Natural Science Foundation of Shanghai [18ZR1404600, 20490710600]
- Shanghai Rising-Star Program [20QA1401200]
- China Postdoctoral Science Foundation [2018M641911, 2018M630397]
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A universal strategy for the synthesis of monodisperse core-shell structured COF nanocomposites remains challenging. The authors have developed a versatile dual-ligand assistant strategy for interfacial growth of COFs on functional nanoparticles with various properties for potential applications in PDT and chemotherapeutic drug delivery. The core@shell structured nanocomposites exhibit controllable shell-thickness and uniformity without agglomeration, making them promising for NIR-activated PDT with deep tissue penetration.
The potential applications of covalent organic frameworks (COFs) can be further developed by encapsulating functional nanoparticles within the frameworks. However, the synthesis of monodispersed core@shell structured COF nanocomposites without agglomeration remains a significant challenge. Herein, we present a versatile dual-ligand assistant strategy for interfacial growth of COFs on the functional nanoparticles with abundant physicochemical properties. Regardless of the composition, geometry or surface properties of the core, the obtained core@shell structured nanocomposites with controllable shell-thickness are very uniform without agglomeration. The derived bowl-shape, yolk@shell, core@satellites@shell nanostructures can also be fabricated delicately. As a promising type of photosensitizer for photodynamic therapy (PDT), the porphyrin-based COFs were grown onto upconversion nanoparticles (UCNPs). With the assistance of the near-infrared (NIR) to visible optical property of UCNPs core and the intrinsic porosity of COF shell, the core@shell nanocomposites can be applied as a nanoplatform for NIR-activated PDT with deep tissue penetration and chemotherapeutic drug delivery. Despite many reports on nanoparticle-covalent organic frameworks (COF) composites, a universal strategy for the synthesis of monodisperse core-shell structured COF nanocomposites remains challenging. Here, the authors develop a strategy for interfacial growth of highly crystalline COFs on functional nanoparticles with abundant optical, electrical and magnetic properties.
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