Related references
Note: Only part of the references are listed.Regulation of human telomerase in homeostasis and disease
Caitlin M. Roake et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation
Corinne Cassani et al.
NUCLEIC ACIDS RESEARCH (2019)
Stepwise 5′ DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble
Elda Cannavo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends
Sarem Hailemariam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex
Lisa Kaeshammer et al.
MOLECULAR CELL (2019)
CDK and Mec1/Tel1-catalyzed phosphorylation of Sae2 regulate different responses to DNA damage
Tai-Yuan Yu et al.
NUCLEIC ACIDS RESEARCH (2019)
The telomere-binding protein Rif2 and ATP-bound Rad50 have opposing roles in the activation of yeast Tel1ATM kinase
Sarem Hailemariam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning
Luca Menin et al.
EMBO REPORTS (2018)
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair
Aleem Syed et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)
Shelterin-Mediated Telomere Protection
Titia de Lange
ANNUAL REVIEW OF GENETICS, VOL 52 (2018)
Regulatory control of DNA end resection by Sae2 phosphorylation
Elda Cannavo et al.
NATURE COMMUNICATIONS (2018)
Tempo and Mode of Genome Evolution in the Budding Yeast Subphylum
Xing-Xing Shen et al.
CELL (2018)
Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection
Tai-Yuan Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
Rekha Rai et al.
MOLECULAR CELL (2017)
Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites
Rajashree A. Deshpande et al.
NUCLEIC ACIDS RESEARCH (2017)
ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
Yaqi Liu et al.
EMBO JOURNAL (2016)
Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
Julyun Oh et al.
MOLECULAR CELL (2016)
Stop pulling my strings - what telomeres taught us about the DNA damage response
Eros Lazzerini-Denchi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks
Corinne Cassani et al.
PLOS BIOLOGY (2016)
Minishelterins separate telomere length regulation and end protection in fission yeast
Lili Pan et al.
GENES & DEVELOPMENT (2015)
Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae
Hannah Kaizer et al.
GENETICS (2015)
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres
Adrian S. Tong et al.
CELL REPORTS (2015)
ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells
Stella Suyong Lee et al.
CELL REPORTS (2015)
Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae
Hannah Kaizer et al.
GENETICS (2015)
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
Rajashree A. Deshpande et al.
EMBO JOURNAL (2014)
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Atsushi Shibata et al.
MOLECULAR CELL (2014)
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
Elda Cannavo et al.
NATURE (2014)
Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions
Tianlai Shi et al.
CELL (2013)
Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation
Ylli Doksani et al.
CELL (2013)
Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
Ji-Hoon Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A two-step mechanism for TRF2-mediated chromosome-end protection
Keiji Okamoto et al.
NATURE (2013)
The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair
Clara Correia Reis et al.
EMBO JOURNAL (2012)
A Balance between Tel1 and Rif2 Activities Regulates Nucleolytic Processing and Elongation at Telomeres
Marina Martina et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Anticheckpoint pathways at telomeres in yeast
Cyril Ribeyre et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
Katja Lammens et al.
CELL (2011)
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
Yong Chen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Cdc13 and Telomerase Bind through Different Mechanisms at the Lagging- and Leading-Strand Telomeres
Virginie Faure et al.
MOLECULAR CELL (2010)
Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair
Jean S. McGee et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
The MRX Complex Plays Multiple Functions in Resection of Yku- and Rif2-Protected DNA Ends
Diego Bonetti et al.
PLOS ONE (2010)
Plasticity of telomere maintenance mechanisms in yeast
Neal F. Lue
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Shelterin-Like Proteins and Yku Inhibit Nucleolytic Processing of Saccharomyces cerevisiae Telomeres
Diego Bonetti et al.
PLOS GENETICS (2010)
DNA end resection: Many nucleases make light work
Eleni P. Mimitou et al.
DNA REPAIR (2009)
Kinase-Independent Functions of TEL1 in Telomere Maintenance
Yunmei Ma et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2
Nadya Dimitrova et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres
Zhong Deng et al.
MOLECULAR CELL (2009)
Rif1 and Rif2 Inhibit Localization of Tel1 to DNA Ends
Yukinori Hirano et al.
MOLECULAR CELL (2009)
Multiple Pathways Regulate 3′ Overhang Generation at S. cerevisiae Telomeres
Diego Bonetti et al.
MOLECULAR CELL (2009)
Multiple roles for MRE11 at uncapped telomeres
Yibin Deng et al.
NATURE (2009)
How Telomeres Solve the End-Protection Problem
Titia de Lange
SCIENCE (2009)
Multiple pathways inhibit NHEJ at telomeres
Stephane Marcand et al.
GENES & DEVELOPMENT (2008)
Telomerase and Tel1p preferentially associate with short telomeres in S-cerevisiae
Michelle Sabourin et al.
MOLECULAR CELL (2007)
The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactis
Sidney D. Carter et al.
GENETICS (2007)
A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint
RJ Michelson et al.
GENES & DEVELOPMENT (2005)
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
ZS You et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae
H Shima et al.
GENETICS (2005)
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
J Falck et al.
NATURE (2005)
Effect of amino acid substitutions in the Rad50 ATP binding domain on DNA double strand break repair in yeast
L Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism
D Nakada et al.
GENES & DEVELOPMENT (2003)
Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae
V Viscardi et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Cancer predisposition and hematopoietic failure in Rad50S/S mice
CF Bender et al.
GENES & DEVELOPMENT (2002)
DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50•Mre11 complex
KM Trujillo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
XD Zhu et al.
NATURE GENETICS (2000)
Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
KP Hopfner et al.
CELL (2000)