Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 22, Issue 3, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2021.10473
Keywords
microRNA-934; colorectal cancer; Dickkopf-related protein 2
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The study identified that miR-934 regulates colorectal cancer cell proliferation by targeting DDK2 in colorectal cancer cells. Knockdown of DDK2 can reverse the inhibitory effects of miR-934, suggesting miR-934 may serve as a potential biomarker for patients with colorectal cancer.
Increasing evidence demonstrates that dysregulation of microRNAs (miRNAs/miRs) is implicated in the development of colorectal cancer. However, the biological functions of several differentially expressed miRNAs remain unknown. In the present study, a bioinformatic analysis of a previously published microarray data and reverse transcription-quantitative PCR analysis demonstrated that miR-934 expression was upregulated in colorectal cancer samples collected from patients. Mechanistically, Dickkopf-related protein 2 (DDK2) was identified as a novel target gene of miR-934 in colorectal cancer cells. Knockdown of DDK2 reversed the inactivation of Wnt signaling pathway induced using miR-934 inhibitor in colorectal cancer cells. In addition, DDK2 silencing reversed miR-934 inhibitor-induced cell proliferation inhibition and elevation of cell apoptosis. The results demonstrated that DDK2 mRNA expression was negatively associated with miR-934 expression in colorectal tumors. Collectively, the results of the present study demonstrated that the miR-934/DDK2 axis regulated colorectal cancer cell proliferation, suggesting that miR-934 may be a biomarker for patients with colorectal cancer.
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