Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 15, Issue 2, Pages 360-380Publisher
SPRINGER
DOI: 10.1007/s12265-021-10169-x
Keywords
Antibody phage display; Cardiovascular disease; Immunotherapy; Monoclonal antibodies; Proprotein convertase subtilisin; kexin type 9; Angiopoietin-like proteins; Apolipoprotein C-III; Activin A receptor type II-like kinase 1; Perilipin; Lipoprotein lipase
Funding
- Malaysian Ministry of Higher Education through the Fundamental Research Grant Scheme [FRGS/1/2018/STG05/USM/02/2]
- Graduate Assistant Scheme from Universiti Sains Malaysia
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Cardiovascular disease is a leading cause of death globally, with the lipid hypothesis proposing a linkage between plasma cholesterol levels and the risk of developing CVD. Monoclonal antibodies can potentially be used for biological interventions to regulate serum cholesterol levels.
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. CVD includes coronary artery diseases such as angina, myocardial infarction, and stroke. Lipid hypothesis which is also known as the cholesterol hypothesis proposes the linkage of plasma cholesterol level with the risk of developing CVD. Conventional management involves the use of statins to reduce the serum cholesterol levels as means for CVD prevention or treatment. The regulation of serum cholesterol levels can potentially be regulated with biological interventions like monoclonal antibodies. Phage display is a powerful tool for the development of therapeutic antibodies with successes over the recent decade. Although mainly for oncology, the application of monoclonal antibodies as immunotherapeutic agents could potentially be expanded to CVD. This review focuses on the concept of phage display for antibody development and discusses the potential target antigens that could potentially be beneficial for serum cholesterol management.
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