The Nuclear Lamina

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that is involved in a variety of cellular processes such as the governance of nuclear integrity, nuclear positioning, mitosis, DNA repair, DNA replication, splicing, signaling, mechanotransduction and -sensation, transcriptional regulation, and genome organization. Lamins are the primary scaffold for this nuclear subcompartment, but interactions with lamin-associated peptides in the inner nuclear membrane are self-reinforcing and mutually required. Lamins also interact, directly and indirectly, with peripheral heterochromatin domains called lamina-associated domains (LADs) and help to regulate dynamic 3D genome organization and expression of developmentally regulated genes.

Automated summary

Lamins interact with various nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, and chromatin itself to form a nuclear subcompartment called the nuclear lamina, which plays important roles in nuclear integrity, cellular positioning, mitosis, DNA repair, and gene regulation. Lamins also interact with lamin-associated peptides and peripheral heterochromatin domains, contributing to dynamic 3D genome organization and the expression of developmentally regulated genes.