Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 14, Issue 1, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a039438
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Funding
- National Institutes of Health (NIH) [T32 GM008061, R01 GM118712, R35GM136419]
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The nuclear pore complex is a channel in the nuclear envelope that controls mRNA export, protein transport, and influences genome organization and function.
The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal loci physically interact with nuclear pore proteins (Nups), and interactions with Nups can promote transcriptional repression, transcriptional activation, and transcriptional poising. Interaction with the NPC also affects the spatial arrangement of genes, interchromosomal clustering, and folding of topologically associated domains. Thus, the NPC is a spatial organizer of the genome and regulator of genome function.
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