4.5 Article

The Systems and Synthetic Biology of Auxin

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COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a040071

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Funding

  1. USDA National Institute of Food and Agriculture [1021738]
  2. National Science Foundation [IOS-1546873]
  3. National Institutes of Health [R01-GM107084]
  4. Howard Hughes Medical Institute Faculty Scholar Program

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Auxin biology has made significant progress in understanding the structures, dynamics, and control of plant growth networks by combining systems biology and synthetic biology. By continuing the collaboration between these approaches, we can further enhance our understanding and ability to manipulate plant growth, development, and physiology through auxin. It is also important to apply similar complementary approaches to analyze and redesign human systems for the improvement of equity and justice.
Auxin biology as a field has been at the forefront of advances in delineating the structures, dynamics, and control of plant growth networks. Advances have been enabled by combining the complementary fields of top-down, holistic systems biology and bottom-up, build-to-understand synthetic biology. Continued collaboration between these approaches will facilitate our understanding of and ability to engineer auxin's control of plant growth, development, and physiology. There is a need for the application of similar complementary approaches to improving equity and justice through analysis and redesign of the human systems in which this research is undertaken.

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