Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 82, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2021.104478
Keywords
Polysaccharide; Characterization; Hypoglycemic activity; Insulin-resistance HepG2 cells
Categories
Funding
- National Key R&D Program of China [2016YFD0400303]
- Natural Science Foundation of Guangdong Province [2017A030311021]
- Guangdong Province YangFan Innovative and Enterpreneurial Research Team Project [2014YT02S029]
- Jiangmen City Science and Technology Plan on Base and Theory Science Research [2018030101020016324]
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A novel polysaccharide (CMP-2B) was extracted and purified from Centipeda minima, showing significant antioxidant and hypoglycemic activities.
A novel polysaccharide (CMP-2B) was purified from Centipeda minima by anion-exchange and gel-permeation chromatography. Structural characterization revealed that CMP-2B was a homogeneous heteropolysaccharide with an average molecular weight of 113.193 KDa. CMP-2B was made up of mannose, galacturonic acid, galactose and arabinose with a molar ratio of 0.27:0.12:0.42:0.17. The backbone chain of CMP-2B consisted of 3,6)-alpha-D-Manp-(1 and 4,6)-beta-D-Galp-(1, and the branches were comprised of 4)-alpha-D-GalpA-(1, 6)-beta-D-Galp-(1, T alpha-L-Araf-(1 and 3)-alpha-L-Araf -(1. Besides, the results of antioxidant assays revealed that CMP-2B possessed signifcant free radical scavenging ability. Moreover, the results of hypoglycemic assays showed that CMP-2B displayed alpha-glucosidase inhibitory activities, and could significantly improve glucose consumption, glycogen synthesis and the activity of pyruvate kinase of insulin-resistance HepG2 cells. Overall, these results suggested that CMP-2B could be a new source for functional foods.
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