Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 84, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2021.104580
Keywords
Malus hupehensis; Hepatoprotective effects; Rifampin; Isoniazid; CYP450; NADPH4
Categories
Funding
- National Natural Science Foundation of China [81903769]
- Scientific Research Project of the Education Department of Hubei Province of China [Q20171202]
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This study demonstrated that the extracts of MH have hepatoprotective effects against RFP+INH-induced liver injury, by reducing liver function markers, increasing antioxidant levels, and reducing pathological tissue damage.
Malus hupehensis (Pamp.) Rehd (MH) is a dual-purpose plant used as medicine and food, which possesses various biological activities including hepatoprotective effect. In this study, the hepatoprotective activity of extracts of MH (MHE) against RFP + INH-induced liver injury was investigated. Animals in model group were given saline and INH + RFP. Animals in MHE groups were given MHE and INH + RFP. Animals in normal control group were given equal volume of saline. Subsequently, blood and liver samples were collected and assessed. MHE significantly alleviated the liver injury, as evidenced by decreased activities of the ALT, AST, TBIL, MDA and GSH-ST, and increased levels of SOD and GSH. MHE also effectively reduced the pathological tissue damage. Moreover, the CYP450 levels, and expression of CYP3A4, CYP2C9 and NADPH4 protein were inhibited by MHE. MHE exerts a protective effect against RFP + INH-induced liver injury in mice, and could be developed as a liver protectant for treatment of DILI.
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