4.3 Review

Cytochrome P450 enzymes: a review on drug metabolizing enzyme inhibition studies in drug discovery and development

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Drug metabolic stability in early drug discovery to develop potential lead compounds

Siva Nageswara Rao Gajula et al.

Summary: Understanding the metabolic stability of a drug substance is crucial for determining dosing and frequency. Modifying lead compounds can improve metabolic stability and reduce dosing frequency. Predicting in vivo total clearance can be done through in vitro intrinsic clearance data and hepatic clearance models.

DRUG METABOLISM REVIEWS (2021)

Review Pharmacology & Pharmacy

In vitro and in vivo methods to assess pharmacokinetic drug- drug interactions in drug discovery and development

Chuang Lu et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2020)

Article Chemistry, Medicinal

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac

Aprajita S. Yadav et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2020)

Review Pharmacology & Pharmacy

Computational prediction of cytochrome P450 inhibition and induction

Harutoshi Kato

DRUG METABOLISM AND PHARMACOKINETICS (2020)

Article Pharmacology & Pharmacy

Quasi-Irreversible Inhibition of CYP2D6 by Berberine

Ha Gyeong Kim et al.

PHARMACEUTICS (2020)

Review Biochemical Research Methods

Pharmacokinetic drug-drug interactions: an insight into recent US FDA-approved drugs for prostate cancer

Siva Nageswara Rao Gajula et al.

BIOANALYSIS (2020)

Review Biochemistry & Molecular Biology

Computational methods and tools to predict cytochrome P450 metabolism for drug discovery

Jonathan D. Tyzack et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

Article Materials Science, Biomaterials

Bioelectrochemical Systems as Technologies for Studying Drug Interactions Related to Cytochrome P450

Victoria V. Shumyantseva et al.

BIONANOSCIENCE (2019)

Review Pharmacology & Pharmacy

Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

Femke M. de Man et al.

CLINICAL PHARMACOKINETICS (2018)

Article Biochemistry & Molecular Biology

WhichP450: a multi-class categorical model to predict the major metabolising CYP450 isoform for a compound

Peter A. Hunt et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2018)

Editorial Material Biochemical Research Methods

Application of in vitro CYP and transporter assays to predict clinical drug-drug interactions

Donna A. Volpe et al.

BIOANALYSIS (2018)

Review Pharmacology & Pharmacy

Drug metabolism in drug discovery and development

Zhoupeng Zhang et al.

ACTA PHARMACEUTICA SINICA B (2018)

Article Biochemistry & Molecular Biology

Assembly of Hepatocyte Spheroids Using Magnetic 3D Cell Culture for CYP450 Inhibition/Induction

Pujan K. Desai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools

Naiem T. Issa et al.

CURRENT DRUG METABOLISM (2017)

Article Electrochemistry

Bioelectrochemistry as a tool for the study of aromatization of steroids by human aromatase

Giovanna Di Nardo et al.

ELECTROCHEMISTRY COMMUNICATIONS (2015)

Article Chemistry, Multidisciplinary

Electrocatalytic cycle of P450 cytochromes: the protective and stimulating roles of antioxidants

V. V. Shumyantseva et al.

RSC ADVANCES (2015)

Review Biophysics

Cytochrome P450 (CYP) enzymes and the development of CYP biosensors

Elizabeth Schneider et al.

BIOSENSORS & BIOELECTRONICS (2013)

Review Peripheral Vascular Disease

Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs

Koichi Ueno et al.

HYPERTENSION RESEARCH (2012)

Review Biochemistry & Molecular Biology

Breakthrough in P450 bioelectrochemistry and future perspectives

Sheila J. Sadeghi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)

Article Chemistry, Medicinal

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

David O. Nettleton et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)

Review Pharmacology & Pharmacy

Novel advances in cytochrome P450 research

Deepika Singh et al.

DRUG DISCOVERY TODAY (2011)

Article Pharmacology & Pharmacy

An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes

Andrew Parkinson et al.

DRUG METABOLISM AND DISPOSITION (2011)

Article Pharmacology & Pharmacy

CYP2D plays a major role in berberine metabolism in liver of mice and humans

Ying Guo et al.

XENOBIOTICA (2011)

Article Chemistry, Analytical

An Electrochemical Microfluidic Platform for Human P450 Drug Metabolism Profiling

Andrea Fantuzzi et al.

ANALYTICAL CHEMISTRY (2010)

Article Biochemical Research Methods

A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s

Kuresh A. Youdim et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2010)

Article Chemistry, Analytical

Ion Trap Array Mass Analyzer: Structure and Performance

Xiaoxu Li et al.

ANALYTICAL CHEMISTRY (2009)

Article Pharmacology & Pharmacy

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

Rowan A. Stringer et al.

DRUG METABOLISM AND DISPOSITION (2009)

Article Chemistry, Medicinal

Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism

Thomas A. Baillie

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

Article Medical Laboratory Technology

Pharmacogenetic Testing in Psychiatry: A Review of Features and Clinical Realities

Jose de Leon et al.

CLINICS IN LABORATORY MEDICINE (2008)

Article Biochemistry & Molecular Biology

Clinical Utility of Microarrays: Current Status, Existing Challenges and Future Outlook

Xinmin Li et al.

CURRENT GENOMICS (2008)

Review Biochemistry & Molecular Biology

The conduct of drug metabolism studies considered good practice (II):: In vitro experiments

Lee Jia et al.

CURRENT DRUG METABOLISM (2007)

Review Chemistry, Multidisciplinary

The evolving role of drug metabolism in drug discovery and development

Lilian G. Yengi et al.

PHARMACEUTICAL RESEARCH (2007)

Article Biochemical Research Methods

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates

Dieter M. Drexler et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2007)

Review Biochemistry & Molecular Biology

Time-dependent CYP inhibition

Robert J. Riley et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)

Article Pharmacology & Pharmacy

Mechanism-based inactivation of human cytochrome P450 enzymes and the prediction of drug-drug interactions

R. Scott Obach et al.

DRUG METABOLISM AND DISPOSITION (2007)

Article Pharmacology & Pharmacy

Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes

Jiang-Wei Zhang et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2006)

Article Pharmacology & Pharmacy

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

RS Obach et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Pharmacology & Pharmacy

High throughput P450 inhibition screens in early drug discovery

G Zlokarnik et al.

DRUG DISCOVERY TODAY (2005)

Article Pharmacology & Pharmacy

Kinetic values for mechanism-based enzyme inhibition: Assessing the bias introduced by the conventional experimental protocol

JS Yang et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2005)

Review Biotechnology & Applied Microbiology

Predicting in vivo drug interactions from in vitro drug discovery data

LC Wienkers et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Review Biochemistry & Molecular Biology

Cytochrome P450 enzymes mechanism based inhibitors: Common sub-structures and reactivity

E Fontana et al.

CURRENT DRUG METABOLISM (2005)

Article Pharmacology & Pharmacy

Prediction of drug metabolism and interactions on the basis of in vitro investigations

O Pelkonen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2005)

Article Pharmacology & Pharmacy

Time response of cytochrome P450 1A2 activity on cessation of heavy smoking

MS Faber et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)

Article Pharmacology & Pharmacy

Time course of recovery of cytochrome P450 3A function after single doses of grapefruit juice

DJ Greenblatt et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2003)

Article Pharmacology & Pharmacy

The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective

TD Bjornsson et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2003)

Review Medicine, General & Internal

Genomic medicine - Inheritance and drug response.

R Weinshilboum

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Review Biochemistry & Molecular Biology

Reaction phenotyping in drug discovery: Moving forward with confidence?

JA Williams et al.

CURRENT DRUG METABOLISM (2003)

Review Biochemistry & Molecular Biology

Cytochrome P450 pharmacogenetics in drug development:: In vitro studies and clinical consequences

AD Rodrigues et al.

CURRENT DRUG METABOLISM (2002)

Article Pharmacology & Pharmacy

Mechanism-based inactivation of cytochrome P450 3A4 by 17α-ethynylestradiol:: Evidence for heme destruction and covalent binding to protein

HL Lin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

Review Pharmacology & Pharmacy

Human drug metabolism and the cytochromes P450: Application and relevance of in vitro models

K Venkatakrishnan et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2001)

Article Chemistry, Medicinal

Role of drug metabolism in drug discovery and development

GN Kumar et al.

MEDICINAL RESEARCH REVIEWS (2001)

Review Biochemistry & Molecular Biology

Screening of drug candidates for their drug-drug interaction potential

AD Rodrigues et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2001)