Journal
FRONTIERS IN NEURAL CIRCUITS
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2021.653116
Keywords
VIP interneurons; medial entorhinal cortex; in vitro patch clamp; characterization; interneurons
Categories
Funding
- McGill University
- Canadian Institutes for Health Research [367017, 377074]
- National Sciences and Engineering Council [74105]
- Scottish Rite Charitable Foundation
- Canada Research Chairs Program
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The study reveals varying gradients in electrophysiological and morphological properties of VIP cells in the medial entorhinal cortex (MEC), with differences across layers and along the dorsal-ventral MEC axis. These results characterize the cellular and morphological properties of VIP cells in the MEC.
Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their activation. Cortical Vasoactive Intestinal Peptide (VIP) expressing inhibitory neurons are known to contact other interneurons and excitatory cells and are thus capable of providing a local disinhibitory mechanism, yet little is known about this cell type in the MEC. To investigate the electrophysiological and morphological properties of VIP cells in the MEC, we use in vitro whole-cell patch-clamp recordings in VIPcre/tdTom mice. We report several gradients in electrophysiological properties of VIP cells that differ across laminae and along the dorsal-ventral MEC axis. We additionally show that VIP cells have distinct morphological features across laminae. Together, these results characterize the cellular and morphological properties of VIP cells in the MEC.
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