Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.720938
Keywords
spinal cord injury; fibrotic scar; crosstalk; cellular origin; treatment strategy
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Funding
- Key Research and Development Projects of Anhui Province [202004j07020042]
- National Natural Science Foundation of China [81801220, 81671204]
- Provincial Natural Science Research Key Project of Colleges and Universities of Anhui Province [KJ2019A0257]
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This study reviews recent advances in fibrotic scar formation after SCI, exploring its interactions with other main cellular components and its potential role as a treatment target for SCI.
The failure of axonal regeneration after spinal cord injury (SCI) results in permanent loss of sensorimotor function. The persistent presence of scar tissue, mainly fibrotic scar and astrocytic scar, is a critical cause of axonal regeneration failure and is widely accepted as a treatment target for SCI. Astrocytic scar has been widely investigated, while fibrotic scar has received less attention. Here, we review recent advances in fibrotic scar formation and its crosstalk with other main cellular components in the injured core after SCI, as well as its cellular origin, function, and mechanism. This study is expected to provide an important basis and novel insights into fibrotic scar as a treatment target for SCI.
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