Journal
CLINICAL NEURORADIOLOGY
Volume 31, Issue 3, Pages 799-810Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00062-021-01033-1
Keywords
Stroke; Endovascular therapy; Outcome; Late thrombectomy
Funding
- Projekt DEAL
Ask authors/readers for more resources
Retrospective analysis of 1917 thrombectomy patients showed that 75% were ineligible for trials due to lack of perfusion imaging, and patients with large CTP lesions in the trial-ineligible group had more hemorrhagic complications and unfavorable outcomes.
Background and Purpose To provide real-world data on outcome and procedural factors of late thrombectomy patients. Methods We retrospectively analyzed patients from the multicenter German Stroke Registry. The primary endpoint was clinical outcome on the modified Rankin scale (mRS) at 3 months. Trial-eligible patients and the subgroups were compared to the ineligible group. Secondary analyses included multivariate logistic regression to identify predictors of good outcome (mRS <= 2). Results Of 1917 patients who underwent thrombectomy, 208 (11%) were treated within a time window >= 6-24 h and met the baseline trial criteria. Of these, 27 patients (13%) were eligible for DAWN and 39 (19%) for DEFUSE3 and 156 patients were not eligible for DAWN or DEFUSE3 (75%), mainly because there was no perfusion imaging (62%; n = 129). Good outcome was not significantly higher in trial-ineligible (27%) than in trial-eligible (20%) patients (p = 0.343). Patients with large trial-ineligible CT perfusion imaging (CTP) lesions had significantly more hemorrhagic complications (33%) as well as unfavorable outcomes. Conclusion In clinical practice, the high number of patients with a good clinical outcome after endovascular therapy >= 6-24 h as in DAWN/DEFUSE3 could not be achieved. Similar outcomes are seen in patients selected for EVT >= 6 h based on factors other than CTP. Patients triaged without CTP showed trends for shorter arrival to reperfusion times and higher rates of independence.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available