4.6 Article

Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone

Journal

VIRUSES-BASEL
Volume 13, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/v13071262

Keywords

Japanese encephalitis virus; West Nile virus; chimera

Categories

Funding

  1. National Project for Prevention and Control of Transboundary Animal Diseases [2017YFD0501800]
  2. Henan Youth Talent Promotion [2021HYTP056]

Ask authors/readers for more resources

West Nile virus disease is caused by the arthropod-borne West Nile virus, posing a significant public health risk. The constructed ChiVax-WN01 chimera exhibits distinct characteristics compared to other strains, with moderate safety and immunogenicity demonstrated in animal studies.
West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prM Delta E gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available