Journal
VIRUSES-BASEL
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/v13060952
Keywords
RNA-binding proteins; RNA viruses; translation control; stress granules; trafficking factors; IRES elements; ER-Golgi; RNA methylation
Categories
Funding
- MINECO [BFU2017-84492-R]
- Autonomous Community of Madrid [B2017/BMD-3770]
- FEDER funds
- Fundacion Ramon Areces
Ask authors/readers for more resources
Viral RNAs rely on host cells to complete their replication cycle, with host proteins playing critical roles in the infection process, and RNA architecture directly impacting virus multiplication and spreading.
Viral RNAs contain the information needed to synthesize their own proteins, to replicate, and to spread to susceptible cells. However, due to their reduced coding capacity RNA viruses rely on host cells to complete their multiplication cycle. This is largely achieved by the concerted action of regulatory structural elements on viral RNAs and a subset of host proteins, whose dedicated function across all stages of the infection steps is critical to complete the viral cycle. Importantly, not only the RNA sequence but also the RNA architecture imposed by the presence of specific structural domains mediates the interaction with host RNA-binding proteins (RBPs), ultimately affecting virus multiplication and spreading. In marked difference with other biological systems, the genome of positive strand RNA viruses is also the mRNA. Here we focus on distinct types of positive strand RNA viruses that differ in the regulatory elements used to promote translation of the viral RNA, as well as in the mechanisms used to evade the series of events connected to antiviral response, including translation shutoff induced in infected cells, assembly of stress granules, and trafficking stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available