Journal
VIRUSES-BASEL
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/v13061174
Keywords
HIV-1; phylogenetics; mixed epidemics; Sub-Saharan Africa; transmission dynamics
Categories
Funding
- Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE), a DELTAS Africa Initiative [DEL-15-006]
- Wellcome Trust [107752/Z/15/Z]
- UK government
- Swedish Research Council [2016-01417]
- Swedish Society for Medical Research [SA-2016]
- U.S. President's Emergency Plan for AIDS Relief (PEPFAR) through the United States Agency for International Development (USAID)
- Medical Faculty at Lund University
- New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency)
- Swedish Research Council [2016-01417] Funding Source: Swedish Research Council
Ask authors/readers for more resources
This review assessed phylogenetic data on HIV-1 transmission dynamics in Sub-Saharan Africa, highlighting the mixing between HIV-1 hotspots and areas with lower HIV-1 burden. It described the HIV-1 transmission from both geographic and risk group perspectives in sSA, as well as discussed the challenges faced in phylogenetic inference in mixed epidemics and potential solutions.
To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995-2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available