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DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
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TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex
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Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses
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Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways
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JOURNAL OF VIROLOGY (2015)
Interferon-Stimulated Genes: A Complex Web of Host Defenses
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ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)
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Enterovirus 2APro Targets MDA5 and MAVS in Infected Cells
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JOURNAL OF VIROLOGY (2014)
The Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus 68 Modulate the Toll-Like Receptor-Induced Proinflammatory Cytokine Response
Kendra A. Bussey et al.
JOURNAL OF VIROLOGY (2014)
Microhomology-based choice of Cas9 nuclease target sites
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HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation
Maria Kalamvoki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Julie Lucifora et al.
SCIENCE (2014)
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
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IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications
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IFITs: emerging roles as key anti-viral proteins
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FRONTIERS IN IMMUNOLOGY (2014)
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CELL (2013)
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Molecular Basis of DNA Recognition in the Immune System
Maninjay K. Atianand et al.
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RIG-I activation inhibits HIV replication in macrophages
Yizhong Wang et al.
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IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus
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The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication
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Structural mechanism of cytosolic DNA sensing by cGAS
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An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
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Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells
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PLOS ONE (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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SCIENCE (2013)
A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses
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Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling
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MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
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ELIFE (2013)
Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response
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IMMUNITY (2012)
ORF45 of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Phosphorylation of Interferon Regulatory Factor 7 by IKKε and TBK1 as an Alternative Substrate
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Arenavirus Nucleoprotein Targets Interferon Regulatory Factor-Activating Kinase IKKε
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Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11
Manqing Li et al.
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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Takafumi Oka et al.
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Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
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HIV Restriction Factors and Mechanisms of Evasion
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Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein
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DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
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IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
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New Insights into the Role of RNase L in Innate Immunity
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RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I
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The IFITM Proteins Inhibit HIV-1 Infection
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Chikungunya Virus Induces IPS-1-Dependent Innate Immune Activation and Protein Kinase R-Independent Translational Shutoff
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Differential Processing of Nuclear Pore Complex Proteins by Rhinovirus 2A Proteases from Different Species and Serotypes
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A diverse range of gene products are effectors of the type I interferon antiviral response
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Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells
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PLOS ONE (2011)
Toll-like receptors: linking inflammation to metabolism
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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection
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Generation of human TRIM5α mutants with high HIV-1 restriction activity
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GENE THERAPY (2010)
Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein
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Interferon-Induced Cell Membrane Proteins, IFITM3 and Tetherin, Inhibit Vesicular Stomatitis Virus Infection via Distinct Mechanisms
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The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15
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Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
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Control of TANK-binding Kinase 1-mediated Signaling by the γ134.5 Protein of Herpes Simplex Virus 1
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NS5 of Dengue Virus Mediates STAT2 Binding and Degradation
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Cleavage of IPS-1 in Cells Infected with Human Rhinovirus
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Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKKε and TBK-1
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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
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MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins
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Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity
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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
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Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
Stuart J. D. Neil et al.
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Viral evasion and subversion of pattern-recognition receptor signalling
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Mrp8 and Mrp14 are endogenous activators of Toll- like receptor 4, promoting lethal, endotoxin-induced shock
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The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA
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5′-triphosphate RNA is the ligand for RIG-I
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif)
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