Journal
VIRUSES-BASEL
Volume 13, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/v13071373
Keywords
CRISPR; Cas; interferon effector proteins; interferon induction; pathogen recognition receptor; pathogen-associated molecular pattern; Toll-like receptor; cGAS; STING; DNA sensors; interferon stimulated genes; pooled libraries; epitranscriptomics; HBV; HDV; HCV; HIV; SARS-CoV-2; yellow fever virus; KSHV; HSV; EBOV; ZIKV; influenza A virus; CHIKV
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Funding
- RFBR-DFG grant [20-515-12010, GL 595/9-1]
- RFBR [20-015-00442]
- German Ministry of Health via the Robert Koch Institute, Berlin, Germany
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Studying and utilizing virus-host interactions are crucial for developing antiviral agents and mitigating the severity of virus-borne infectious diseases, in which CRISPR systems have played a significant role.
Viral infections cause a variety of acute and chronic human diseases, sometimes resulting in small local outbreaks, or in some cases spreading across the globe and leading to global pandemics. Understanding and exploiting virus-host interactions is instrumental for identifying host factors involved in viral replication, developing effective antiviral agents, and mitigating the severity of virus-borne infectious diseases. The diversity of CRISPR systems and CRISPR-based tools enables the specific modulation of innate immune responses and has contributed impressively to the fields of virology and immunology in a very short time. In this review, we describe the most recent advances in the use of CRISPR systems for basic and translational studies of virus-host interactions.
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