4.6 Review

Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69-V70, France, August to December 2020

Antonin Bal et al.

Summary: The study reported the strategy leading to the first detection of the variant of concern 202012/01 (VOC) in France, by screening for mutations such as Delta H69/Delta V70 associated with VOC and identifying co-occurring mutations like S:N501Y.

EUROSURVEILLANCE (2021)

Letter Infectious Diseases

Introduction of the South African SARS-CoV-2 variant 501Y.V2 into the UK

Julian W. Tang et al.

JOURNAL OF INFECTION (2021)

Article Medicine, General & Internal

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

D. M. Weinreich et al.

Summary: Recent data indicate that complications and death from Covid-19 may be related to high viral loads. In this trial involving nonhospitalized patients, a cocktail of two neutralizing monoclonal antibodies (REGN-COV2) reduced viral load, with a greater effect in patients with no immune response or high viral load at baseline. Safety outcomes were similar between REGN-COV2 dose groups and the placebo group.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Editorial Material Medicine, General & Internal

SARS-CoV-2 Viral Variants-Tackling a Moving Target

John R. Mascola et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Editorial Material Medicine, General & Internal

SARS-CoV-2 Vaccines

C. Buddy Creech et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Editorial Material Medicine, General & Internal

SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants

John P. Moore et al.

Summary: This article reviews the circulating SARS-CoV-2 genetic variants and the mechanisms of immunity by which they may escape vaccine-induced protection, proposing 6 measures to address these issues, including enhanced variant isolation and testing procedures, and continued adherence to mask-wearing and other established public health measures.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Medicine, Research & Experimental

Targets and strategies for vaccine development against SARS-CoV-2

Jonaid Ahmad Malik et al.

Summary: The article discusses the importance of developing vaccines against SARS-CoV-2, potential antigen targets, challenges encountered in vaccine development, and methods for overcoming these challenges.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Biochemistry & Molecular Biology

On the origin and evolution of SARS-CoV-2

Devika Singh et al.

Summary: The genome evolution of the coronavirus SARS-CoV-2 has played a crucial role in the development of COVID-19, with evidence of ancestral recombination events and natural selection. The spike protein of the virus shows significant signs of evolutionary processes, facilitating its spillover from other animals to humans. The global spread of SARS-CoV-2 has increased mutational variability in its genome, potentially leading to future recombination events.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Review Urology & Nephrology

Evolution of SARS-CoV-2: Review of Mutations, Role of the Host Immune System

Helene Banoun

Summary: The article emphasizes on the mutations that have occurred in the virus since the beginning of the COVID-19 pandemic, as well as the cross-reactivity between common cold coronaviruses and SARS-CoV-2 in a majority of the population. Important evolutionary mutations have emerged in genes encoding proteins that interact with the host immune system, such as viral polymerase. The relationship between cross-reactivity and viral mutations may partly explain the evolution of the pandemic until the summer of 2020.

NEPHRON (2021)

Article Immunology

SARS-CoV-2 Transmission between Mink (Neovison vison) and Humans, Denmark

Anne Sofie Hammer et al.

Summary: Novel virus variants in farmed mink in Denmark were found to subsequently appear in the local human community, highlighting the potential for interspecies transmission of the virus.

EMERGING INFECTIOUS DISEASES (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

Yixuan J. Hou et al.

Article Medicine, General & Internal

SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate

Manuel Becerra-Flores et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2020)

Article Infectious Diseases

Viable SARS-CoV-2 in various specimens from COVID-19 patients

Hye Won Jeong et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

Review Critical Care Medicine

Acute kidney injury in critically ill patients with COVID-19

Paul Gabarre et al.

INTENSIVE CARE MEDICINE (2020)

Review Immunology

Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past

Vibhuti Kumar Shah et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Leonid Yurkovetskiy et al.

Article Medicine, General & Internal

An mRNA Vaccine against SARS-CoV-2-Preliminary Report

L. A. Jackson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

Deciphering SARS-CoV-2 Virologic and Immunologic Features

Gregorie Lebeau et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

Gregory A. Poland et al.

LANCET (2020)

News Item Multidisciplinary Sciences

MAKING SENSE OF CORONAVIRUS MUTATIONS

Ewen Callaway

NATURE (2020)

Review Biochemistry & Molecular Biology

A systematic review of SARS-CoV-2 vaccine candidates

Yetian Dong et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Endocrinology & Metabolism

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response

Indwiani Astuti et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Article Cell Biology

The origin and underlying driving forces of the SARS-CoV-2 outbreak

Shu-Miaw Chaw et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Letter Immunology

Infectious SARS-CoV-2 in Feces of Patient with Severe COVID-19

Fei Xiao et al.

EMERGING INFECTIOUS DISEASES (2020)

Review Medicine, Research & Experimental

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

Marco Tuccori et al.

Review Biochemistry & Molecular Biology

SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat

Jun Zheng

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of HIV-1 Genetic Diversity

D. V. Sosin et al.

MOLECULAR BIOLOGY (2017)

Article Virology

High-throughput profiling of point mutations across the HIV-1 genome

Laith Q. Al-Mawsawi et al.

RETROVIROLOGY (2014)

Article Multidisciplinary Sciences

The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia

Rebecca L. Dunfee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)