Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and-2

Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is imperative that we provide interventions to keep them at bay, especially in immunocompromised patients. While numerous experimental vaccines are under consideration, current intervention consists solely of antiviral chemotherapeutic agents. This review explores all of the clinically approved drugs used to prevent the worst sequelae of recurrent outbreaks by these viruses.

Automated summary

Herpes simplex viruses-1 and -2 can cause lifelong infections, especially posing a greater threat to immunocompromised patients, hence the need for interventions. Experimental vaccines are still under consideration, and current treatment relies solely on antiviral medications.