4.6 Review

Beta-Genus Human Papillomavirus 8 E6 Destabilizes the Host Genome by Promoting p300 Degradation

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Current development of CBP/p300 inhibitors in the last decade

Zhang-Xu He et al.

Summary: CBP/p300, as a potential target for treating diseases including malignant tumors, has attracted interest in the development of small-molecule inhibitors. The review focuses on the development of CBP/p300 inhibitors from 2010 to 2020, highlighting their structure-activity relationships, binding modes, selectivity, and pharmacological functions to facilitate rational design and development of potential inhibitors.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Genetics & Heredity

Effects of β-HPV on DNA damage response pathways to drive carcinogenesis: a review

Danyal Tahseen et al.

Summary: DDR is a complex signaling network responsible for maintaining genomic integrity. Beta-HPVs destabilize the host genome by attenuating DDR, enhancing the oncogenicity of UV-induced mutations and enabling carcinogenesis. Understanding the pathomechanism of beta-HPVs and developing targeted molecular therapies for related cancers are of significance.

VIRUS GENES (2021)

Article Biochemistry & Molecular Biology

Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

Natalia Sanz-Gomez et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Biochemistry & Molecular Biology

Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins

Adrian Campos et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Medicinal

Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors

Yaxi Yang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Oncology

DNA Damage/Repair Management in Cancers

Jehad F. Alhmoud et al.

CANCERS (2020)

Editorial Material Multidisciplinary Sciences

Reply to: Beta human papillomaviruses and skin cancer

John D. Strickley et al.

NATURE (2020)

Editorial Material Multidisciplinary Sciences

Beta human papillomaviruses and skin cancer

Paul F. Lambert et al.

NATURE (2020)

Review Oncology

Mutant p53 in Cancer Progression and Targeted Therapies

Gaoyang Zhu et al.

FRONTIERS IN ONCOLOGY (2020)

Review Cell Biology

The multiple mechanisms that regulate p53 activity and cell fate

Antonina Hafner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Biology

Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance

Assunta Venuti et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)

Review Oncology

DNA-PK as an Emerging Therapeutic Target in Cancer

Ismail S. Mohiuddin et al.

FRONTIERS IN ONCOLOGY (2019)

Review Biotechnology & Applied Microbiology

DNA repair in cancer initiation, progression, and therapy-a double-edged sword

Katarzyna Kiwerska et al.

JOURNAL OF APPLIED GENETICS (2019)

Review Cell Biology

The DNA damage response to transcription stress

Hannes Lans et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Immunity to commensal papillomaviruses protects against skin cancer

John D. Strickley et al.

NATURE (2019)

Article Microbiology

β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage

Jazmine A. Snow et al.

PATHOGENS (2019)

Review Cell Biology

Functions and mechanisms of non-histone protein acetylation

Takeo Narita et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Pathology

Beta Human Papillomavirus and Associated Diseases

Laura Sichero et al.

ACTA CYTOLOGICA (2019)

Review Virology

HPV and skin carcinogenesis

Massimo Tommasino

PAPILLOMAVIRUS RESEARCH (2019)

Review Virology

Structural Insights in Multifunctional Papillomavirus Oncoproteins

Irina Suarez et al.

VIRUSES-BASEL (2018)

Review Microbiology

Inhibition of TGF-beta and NOTCH Signaling by Cutaneous Papillomaviruses

Jordan M. Meyers et al.

FRONTIERS IN MICROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

p53 shades of Hippo

Noa Furth et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Biochemistry & Molecular Biology

CREBBP and p300 lysine acetyl transferases in the DNA damage response

Ilaria Dutto et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Article Biochemistry & Molecular Biology

The Papillomavirus Episteme: a major update to the papillomavirus sequence database

Koenraad Van Doorslaer et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Medicine, Research & Experimental

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer

Narsis Attar et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

Article Immunology

Prevalence and Concordance of Cutaneous Beta Human Papillomavirus Infection at Mucosal and Cutaneous Sites

Shalaka S. Hampras et al.

JOURNAL OF INFECTIOUS DISEASES (2017)

Review Biochemistry & Molecular Biology

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Andrew N. Blackford et al.

MOLECULAR CELL (2017)

Review Virology

The biology of beta human papillomaviruses

Massimo Tommasino

VIRUS RESEARCH (2017)

Review Microbiology

Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response

Sebastian O. Wendel et al.

FRONTIERS IN MICROBIOLOGY (2017)

Article

Epidermodysplasia Verruciformis: An Early and Unusual Presentation

Ilteris Murat Emsen et al.

Canadian Journal of Plastic Surgery (2017)

Article Cell Biology

Exploiting DNA repair defects for novel cancer therapies

Dik C. van Gent et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

Review Cell Biology

Repair Pathway Choices and Consequences at the Double-Strand Break

Raphael Ceccaldi et al.

TRENDS IN CELL BIOLOGY (2016)

Article Medicine, Research & Experimental

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

Jiandong Chen

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Review Chemistry, Multidisciplinary

Protein Lysine Acetylation by p300/CBP

Beverley M. Dancy et al.

CHEMICAL REVIEWS (2015)

Article Biochemistry & Molecular Biology

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis

Martin Hufbauer et al.

MOLECULAR CANCER (2015)

Article Biochemistry & Molecular Biology

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

A. Bakr et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Virology

Beta genus papillomaviruses and skin cancer

Peter M. Howley et al.

VIROLOGY (2015)

Article Biochemistry & Molecular Biology

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

Simon A. Forbes et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

Neil J. Ganem et al.

Article Biochemistry & Molecular Biology

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

Jayne Loughery et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair

T-H Lee et al.

ONCOGENE (2014)

Article Biochemistry & Molecular Biology

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation

Manuela Delvecchio et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

Orit Rozenblatt-Rosen et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

How viruses affect the cell cycle through manipulation of the APC/C

Min Mo et al.

TRENDS IN MICROBIOLOGY (2012)

Review Cell Biology

The Causes and Consequences of Polyploidy in Normal Development and Cancer

Teresa Davoli et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Article Microbiology

Beta-HPV 5 and 8 E6 Promote p300 Degradation by Blocking AKT/p300 Association

Heather L. Howie et al.

PLOS PATHOGENS (2011)

Article Oncology

Role of p53 in Cell Death and Human Cancers

Toshinori Ozaki et al.

Cancers (2011)

Article Cell Biology

Mechanism of p53 stabilization by ATM after DNA damage

Qian Cheng et al.

CELL CYCLE (2010)

Article Biotechnology & Applied Microbiology

Epidermodysplasia verruciformis and susceptibility to HPV

Tejas Patel et al.

DISEASE MARKERS (2010)

Review Biochemistry & Molecular Biology

The DNA Damage Response: Making It Safe to Play with Knives

Alberto Ciccia et al.

MOLECULAR CELL (2010)

Review Biochemistry & Molecular Biology

p53 post-translational modification: deregulated in tumorigenesis

Chao Dai et al.

TRENDS IN MOLECULAR MEDICINE (2010)

Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

Article Multidisciplinary Sciences

A mechanism linking extra centrosomes to chromosomal instability

Neil J. Ganem et al.

NATURE (2009)

Review Oncology

Tumour suppression by p53: a role for the DNA damage response?

David W. Meek

NATURE REVIEWS CANCER (2009)

Article Cell Biology

The consequences of tetraploidy and aneuploidy

Zuzana Storchova et al.

JOURNAL OF CELL SCIENCE (2008)

Review Cell Biology

Regulation of DNA repair throughout the cell cycle

Dana Branzei et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Biotechnology & Applied Microbiology

Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses

Stephanie Toepffer et al.

JOURNAL OF GENERAL VIROLOGY (2007)

Article Biochemistry & Molecular Biology

p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint

Daniel Stauffer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Genetics & Heredity

Mammalian single-strand break repair: Mechanisms and links with chromatin

Keith W. Caldecott

DNA REPAIR (2007)

Article Biochemistry & Molecular Biology

Akt-phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity

WC Huang et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Review Biochemistry & Molecular Biology

DNA damage-induced apoptosis

CJ Norbury et al.

ONCOGENE (2004)

Article Pharmacology & Pharmacy

CBP and p300: HATs for different occasions

E Kalkhoven

BIOCHEMICAL PHARMACOLOGY (2004)

Article Multidisciplinary Sciences

Cell-cycle checkpoints and cancer

MB Kastan et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

p300/CBP and cancer

NG Iyer et al.

ONCOGENE (2004)

Article Multidisciplinary Sciences

P300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels

NG Iyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Medicine, General & Internal

Epidermodysplasia verruciformis

JE Lane et al.

SOUTHERN MEDICAL JOURNAL (2003)

Review Genetics & Heredity

Histone acetyl transferases: a role in DNA repair and DNA replication

S Hasan et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2002)

Review Oncology

Centrosome replication, genomic instability and cancer

A Krämer et al.

LEUKEMIA (2002)

Article Biochemistry & Molecular Biology

Acetyltransferase machinery conserved in p300/CBP-family proteins

LWC Yuan et al.

ONCOGENE (2002)

Article Cell Biology

Acetylation control of the retinoblastoma tumour-suppressor protein

HM Chan et al.

NATURE CELL BIOLOGY (2001)

Review Multidisciplinary Sciences

Genome maintenance mechanisms for preventing cancer

JHJ Hoeijmakers

NATURE (2001)

Review Biochemistry & Molecular Biology

p300/CBP/p53 interaction and regulation of the p53 response

SR Grossman

EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)

Review Oncology

Cell cycle and apoptosis

B Pucci et al.

NEOPLASIA (2000)

Article Genetics & Heredity

Mutations truncating the EP300 acetylase in human cancers

SA Gayther et al.

NATURE GENETICS (2000)