Sex difference in lipid levels in first-diagnosed drug-naive depression patients: A case-control and 12-weeks follow-up study

Aim Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included. Methods The study included 56 healthy controls (males/females = 26/30) and 110 first-diagnosed drug-naive outpatients (males/females = 35/75). A total of 42 patients (males/females = 14/28) were followed for 3 months. Results A significant difference was found in TCH and LDL-C among healthy control and patients. Interestingly, female patients with first-diagnosed, drug-naive depression had lower atherogenic indices than male patients. After 3 months of antidepressants therapy, female patients exhibited detrimental changes in serum lipids, namely increased TG and atherogenic index. Moreover, correlation analysis showed significant correlations between changes of depression inventory (HAMD and BDI) score and serum lipids (TCH, HDL-C) in depressed patients. Conclusion We found that dyslipidemia was more common in female patients with depression during therapy with antidepressants. Moreover, the altered serum lipids and atherogenic index might be a hallmark of female patients. Further investigation of sex differences in lipid metabolism of depression is warranted.

Automated summary

Depressed patients, especially females, have a higher prevalence of dyslipidemia. Female patients with first-diagnosed, drug-naive depression showed lower atherogenic indices compared to male patients, but exhibited detrimental changes in serum lipids after 3 months of antidepressants therapy. Significant correlations were found between changes in depression inventory scores and serum lipids in depressed patients, suggesting a possible relationship between depression and dyslipidemia.