Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Volume 23, Issue 4, Pages 264-277Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2021.1966714
Keywords
Social dysfunction; DMN; schizophrenia; Alzheimer's; transdiagnostic
Categories
Funding
- Innovative Medicines Initiative 2 Joint Undertaking [115916]
- European Union
- EFPIA
Ask authors/readers for more resources
The study found a correlation between social dysfunction and reduced DMN connectivity, with the combined effect of both being more pronounced, independent of diagnostic status and not confounded by key clinical or sociodemographic effects.
Objectives Social dysfunction is one of the most common signs of major neuropsychiatric disorders. The Default Mode Network (DMN) is crucially implicated in both psychopathology and social dysfunction, although the transdiagnostic properties of social dysfunction remains unknown. As part of the pan-European PRISM (Psychiatric Ratings using Intermediate Stratified Markers) project, we explored cross-disorder impact of social dysfunction on DMN connectivity. Methods We studied DMN intrinsic functional connectivity in relation to social dysfunction by applying Independent Component Analysis and Dual Regression on resting-state fMRI data, among schizophrenia (SZ; N = 48), Alzheimer disease (AD; N = 47) patients and healthy controls (HC; N = 55). Social dysfunction was operationalised via the Social Functioning Scale (SFS) and De Jong-Gierveld Loneliness Scale (LON). Results Both SFS and LON were independently associated with diminished DMN connectional integrity within rostromedial prefrontal DMN subterritories (p(corrected) range = 0.02-0.04). The combined effect of these indicators (Mean.SFS + LON) on diminished DMN connectivity was even more pronounced (both spatially and statistically), independent of diagnostic status, and not confounded by key clinical or sociodemographic effects, comprising large sections of rostromedial and dorsomedial prefrontal cortex (p(corrected)=0.01). Conclusions These findings pinpoint DMN connectional alterations as putative transdiagnostic endophenotypes for social dysfunction and could aid personalised care initiatives grounded in social behaviour.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available