Journal
VACCINE
Volume 39, Issue 34, Pages 4759-4765Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2021.06.083
Keywords
CYD-TDV; Dengue vaccine; Dengvaxia; Serostatus; Screening; Test and vaccinate; Rapid diagnostic tests; Label change
Categories
Funding
- Sanofi Pasteur
- Takeda
- Bill&Melinda Gates Foundation
Ask authors/readers for more resources
The implementation strategies for the use of the dengue vaccine CYD-TDV are being adjusted, including reducing the number of doses, expanding the age range and indication, developing school-based vaccination plans, etc. Challenges remain, such as communicating the limitation of vaccine use to seropositive individuals, economic affordability in different countries, government commitment, and community acceptance.
Dengue vaccination would enhance the control of dengue, one of the most frequent vector-borne viral diseases globally. CYD-TDV is the first dengue vaccine to be licensed, but global uptake has been hampered due to its use being limited to seropositive persons aged 9 years and above, and the need for a 3-dose schedule. The Partnership for Dengue Control (PDC) organized a meeting with key opinion leaders and stakeholders to deliberate on implementation strategies for the use of CYD-TDV. New data have emerged that support the shortening of the primary schedule from a 3 to 2 dose schedule, extending the age range below 9 to 6 years of age, and expanding the indication from endemic populations to also include travelers to endemic areas. Cost-effectiveness may improve with the modified 2-dose regimen and with multiple testing. Strategies to implement a dengue vaccination program have been developed, in particular school-based strategies. A range of delivery scenarios can then be considered, using various settings for each step of the intervention. However, several challenges remain, including communication about limiting the use of this vaccine to seropositive individuals only. Affordability will vary from country to country, as will government commitment and community acceptance. Well-tailored communication strategies that target key stakeholders are expected to make up a significant part of any future dengue vaccination program.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available