Journal
TRENDS IN PARASITOLOGY
Volume 37, Issue 9, Pages 777-779Publisher
CELL PRESS
DOI: 10.1016/j.pt.2021.07.008
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Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [240245660 - SFB 1129]
- Baden-Wurttemberg Foundation [1.16101.17]
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Plasmodium merozoites invade erythrocytes through ligand binding, calcium signaling, and membrane deformation in a stepwise manner. Geoghegan et al. utilized a newly developed light sheet microscope to investigate invasion with unprecedented temporal resolution, revealing the roles of host cell cholesterol and pore formation at the parasite-host cell interface.
Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite-host cell interface.
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