Journal
TRENDS IN PARASITOLOGY
Volume 38, Issue 1, Pages 67-79Publisher
CELL PRESS
DOI: 10.1016/j.pt.2021.07.009
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Funding
- European Union [TMA2016CDF-1571]
- African Academy of Sciences - UK Government's Global Challenges Research Fund [FLR\R1\191058]
- Royal Society - UK Government's Global Challenges Research Fund [FLR\R1\191058]
- Poliomyelitis Research Foundation of South Africa [18/19]
- International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town component
- National Institute for Health Research (NIHR) [RSTMH\2019\12837708]
- UK Royal Society FLAIR [FLR\R1\191058]
- South African National Research Foundation (NRF)
- University of Cape Town
- Poliomyelitis Research Foundation of South Africa
- South African Medical Re-search Council (SAMRC)
- Commonwealth Professional Fellowship Award from the Common-wealth Scholarship Commission (CSC)
- International Centre for Genetic Engineering and Biotechnology, Cape Town component
- South African National Research Foundation
- Med-ical Research Council
- CIDRI-Africa [203135/Z/16/Z]
- [117840]
- [NGCP-2019-61]
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Studies have shown that schistosomiasis can interfere with the host's ability to mount immune responses to unrelated antigens, highlighting the importance of assessing the impact of this disease on host vaccine responses. There is currently no consensus on the influence of schistosomiasis on host vaccine responses.
Schistosomiasis is a debilitating helminthiasis which commonly establishes as a chronic infection in people from endemic areas. As a potent modulator of the host immune response, the Schistosoma parasite and its associated products can directly interfere with its host's ability to mount adequate immune responses to un-related antigens. As a result, increased attention is gathering on studies assessing the influence of helminths, particularly the causal agent of schistosomiasis, on host responsiveness to vaccines. However, to date, no consensus has been drawn regarding the influence of schistosomiasis on host vaccine responses. Here, we review available evidence on the influence of transgenerational and direct Schistosoma parasite exposure on host immune responses to unrelated vaccines. In addition, we evaluate the potential of praziquantel (PZQ) treatment in restoring schistosomiasis-impacted vaccine responses.
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