Clinical implications of vitamin B12 as redox-active cofactor

Vitamin B-12 is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B-12 may be clinically used to reduce oxidative stress and preserve cofactor functions.

Automated summary

Vitamin B-12 is a redox-active compound that plays a crucial role in maintaining gene expression and energy production in the body. High doses of vitamin B-12 can be used clinically to reduce oxidative stress and preserve cofactor functions.