Journal
TRENDS IN MICROBIOLOGY
Volume 30, Issue 2, Pages 158-169Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.05.005
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Funding
- University of Queensland PhD scholarship - UQ Diamantina Institute Laboratory Start-Up Package
- Cure Cancer Australia [1158085]
- US Department of Defence - Breast Cancer Research Program - Breakthrough Award [BC200025]
- National Health and Medical Research Council of Australia (NHMRC) [APP1162522]
- Queensland Government
- Australian Government
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Immunotherapies are being explored as potential alternatives to traditional antimicrobial therapy in order to combat antibiotic-resistant bacteria and their ability to evade the immune response.
The emergence of multiantibiotic-resistant bacteria, often referred to as superbugs, is leading to infections that are increasingly difficult to treat. Further, bacteria have evolved mechanisms by which they subvert the immune response, meaning that even antibiotic-sensitive bacteria can persist through antibiotic therapy. For these reasons, a broad range of viable therapeutic alternatives or conjunctions to traditional antimicrobial therapy are urgently required to reduce the burden of disease threatened by antibiotic resistance. Immunotherapy has emerged as a leading treatment option in cancer, and researchers are now attempting to apply this to infectious disease. This review summarizes and discusses the recent advances in the field and highlights current and future perspectives of using immunotherapies to treat bacterial infections.
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