Journal
TRENDS IN MICROBIOLOGY
Volume 30, Issue 4, Pages 322-329Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.08.007
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Funding
- Quadram Institute Bioscience BBSRC [BB/R012504/1, BBS/E/F/000PR10351 (Theme 3)]
- [BBS/E/F/000PR10351]
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This article discusses the potential importance of the oesophageal microbiome and introduces new research methods that offer hope for a comprehensive description of this microbial community.
The human oesophagus is home to a complex microbial community, the oesophageal microbiome. Despite decades of work, we still have only a poor, low-resolution view of this community, which makes it hard to distinguish hope from hype when it comes to assessing links between the oesophageal microbiome and cancer. Here we review the potential importance of this microbiome and discuss new approaches, including culturomics, metagenomics, and recovery of whole-genome sequences, that bring renewed hope for an in-depth characterisation of this community that could deliver translational impact.
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