Journal
TRENDS IN IMMUNOLOGY
Volume 42, Issue 10, Pages 841-843Publisher
CELL PRESS
DOI: 10.1016/j.it.2021.08.007
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Funding
- European Research Council [742883, Sonderforschungsbereich 873-B11]
- Leibniz program of the Deutsche Forschungsgemeinschaft
- European Research Council (ERC) [742883] Funding Source: European Research Council (ERC)
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The study identified perivascular stromal cells in the bone marrow that coexpress osteolectin and leptin receptor and play important roles in supporting lymphoid progenitors and serving as osteoblast progenitors, while being maintained by mechanical stimulation. This suggests that exercise may have positive effects on lymphopoiesis and bone formation by targeting these specific cell populations.
Using newly developed reporter and lineage-tracing mice, Shen et al. found perivascular stromal cells coexpressing osteolectin and leptin receptor in the bone marrow that specifically supported lymphoid progenitors, served as osteoblast progenitors, and were maintained by mechanical stimulation. Exercise may thus have joint positive influences on lymphopoiesis and bone formation.
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