Journal
TRENDS IN IMMUNOLOGY
Volume 42, Issue 9, Pages 764-781Publisher
CELL PRESS
DOI: 10.1016/j.it.2021.07.002
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Funding
- Italian Ministry of Health [RF-2019-12371549]
- Italian Ministry of University [20174T7NXL]
- Fondazione Regionale Ricerca Biomedica (NEVERMIND project)
- AIRC 5x1000 [21147]
- Italian Foundation for Cancer Research
- European Federation of Immunological Societies (EFIS)-IL short-term fellowship
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The MS4A family members have differential and selective expression in immunocompetent cells and modulate the signaling activity of various immunoreceptors. Studies suggest that they play key roles in different pathological settings such as cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members could be potential candidate biomarkers and therapeutic targets for various conditions.
The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.
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